MiR-497-5p regulates ox-LDL-induced dysfunction in vascular endothelial cells by targeting VEGFA/p38/MAPK pathway in atherosclerosis

MiR-497-5p regulates ox-LDL-induced dysfunction in vascular endothelial cells by targeting VEGFA/p38/MAPK pathway in atherosclerosis

Background: The impairment of endothelial cells triggered by oxidized low-density lipoprotein (ox-LDL) stands as a critical event in the advancement of atherosclerosis (AS). MiR-497-5p has been recognized as a potential predictor for AS, but its precise involvement in ox-LDL-induced endothelial cell...

Bibliografske podrobnosti
Main Authors:	Wei Lu, Guoqing Wan, He Zhu, Tao Zhu, Xinmei Zhang
Format:	Article
Jezik:	English
Izdano:	Elsevier 2024-04-01
Serija:	Heliyon
Teme:	Atherosclerosis HUVECs Ox-LDL miR-497-5p VEGFA p38
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2405844024049181

Podobne knjige/članki

Okside-LDL ve Reseptörü Lektin Benzeri Ox-LDL Reseptör-1
od: Ümmügülsüm Can
Izdano: (2016-12-01)

An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis
od: Jingjing Guo, et al.
Izdano: (2024-10-01)

The effect of ox-LDL and platelets on macrophages, M2 macrophage polarization, and foam cell formation
od: Fatemeh Barati, et al.
Izdano: (2023-01-01)

Effect of Shentongzhuyu Decoction on p38MAPK Signal Pathway in Annulus Fibrosus Cells of Model Rats with Lumbar Disc Degeneration
od: Sha CHEN, et al.
Izdano: (2015-12-01)

p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease
od: Xiao-Mei Qi, et al.
Izdano: (2023-06-01)

Homeopathic preparation of Allium sativum abrogates OxLDL mediated atherogenic events in macrophages: An in vitro and in silico approach
od: Thangarajeswari Mohan, et al.
Izdano: (2024-01-01)

Electronegative LDL Is Associated with Plaque Vulnerability in Patients with Ischemic Stroke and Carotid Atherosclerosis
od: Núria Puig, et al.
Izdano: (2023-02-01)

Knockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3
od: Chongxin Li, et al.
Izdano: (2023-12-01)

Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
od: Jianjie Rong, et al.
Izdano: (2023-12-01)

Metformin Inhibits the Progression of Pancreatic Cancer Through Regulating miR‐378a‐3p/VEGFA/RGC‐32 Axis
od: Jinli He, et al.
Izdano: (2024-12-01)

Retracted: MiR‐497‐5p inhibits cell proliferation and metastasis in hepatocellular carcinoma by targeting insulin‐like growth factor 1
od: Guo‐shu Xu, et al.
Izdano: (2019-10-01)

Regulatory Effect of miR497-5p–CCNE1 Axis in Triple-Negative Breast Cancer Cells and Its Predictive Value for Early Diagnosis [Retraction]
od: Liu WW, et al.
Izdano: (2023-11-01)

Oxidative low-density lipoprotein oxLDL induces pyroptosis in trophoblast cells HTR-8/Svneo by downregulating TET2
od: Ting TAO, et al.
Izdano: (2022-12-01)

Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
od: Tan Chujun, et al.
Izdano: (2024-06-01)

OxLDL/LOX-1 mediated sex, age, stiffness, and endothelial dependent alterations in mouse thoracic aortic vascular reactivity
od: Trevor S. Wendt, et al.
Izdano: (2024-11-01)

The protective effects of aloperine against ox-LDL-induced endothelial dysfunction and inflammation in HUVECs
od: Weiwei Li, et al.
Izdano: (2020-01-01)

Helicobacter pylori-induced fibroblast-derived Serpin E1 promotes gastric cancer growth and peritoneal dissemination through p38 MAPK/VEGFA-mediated angiogenesis
od: Wei Cheng, et al.
Izdano: (2023-12-01)

miR-199-3p inhibits diabetes retinopathy in rats by targeting at VegfA
od: ZHOU Yue, LIN Jingna
Izdano: (2023-07-01)

Deletion of p38 MAPK in macrophages ameliorates peritoneal fibrosis and inflammation in peritoneal dialysis
od: Akie Ikushima, et al.
Izdano: (2024-09-01)

p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
od: Ali Ahmadi, et al.
Izdano: (2023-11-01)

Critical Role of p38α MAPK Subclass in the Development of Pain Hypersensitivity After Hind Paw Incision
od: Ishikawa D, et al.
Izdano: (2025-02-01)

Super Carbonate Apatite-miR-497a-5p Complex Is a Promising Therapeutic Option against Inflammatory Bowel Disease
od: Naoto Tsujimura, et al.
Izdano: (2023-04-01)

Spleen tyrosine kinase inhibition mitigates radiation-induced lung injury through anti-inflammatory effects and downregulation of p38 MAPK and p53
od: Guoxing Zhang, et al.
Izdano: (2024-11-01)

MiR-6839-5p inhibits cell proliferation, migration and invasion; a possible correlation with the suppressing VEGFA expression in human chondrosarcoma cells
od: Fusheng Li, et al.
Izdano: (2024-05-01)

Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33
od: Annemarie Witz, et al.
Izdano: (2023-07-01)

LY86 facilitates ox-LDL-induced lipid accumulation in macrophages by upregulating SREBP2/HMGCR expression
od: Guangwei Jiang, et al.
Izdano: (2024-05-01)

GLUT2 regulation of p38 MAPK isoform protein expression and p38 phosphorylation in male versus female rat hypothalamic primary astrocyte Cultures
od: Madhu Babu Pasula, et al.
Izdano: (2024-06-01)

LncRNA XIST promotes neovascularization in diabetic retinopathy by regulating miR-101-3p/VEGFA
od: Weina Fu, et al.
Izdano: (2024-06-01)

Oxidized low-density lipoprotein contributes to injury of endothelial cells via the circ_0090231/miR-9-5p/TXNIP axis
od: Xiubing Lei, et al.
Izdano: (2022-02-01)

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin‐induced apoptosis mediated by reactive oxygen species and JNK
od: Lorena Pereira, et al.
Izdano: (2013-09-01)

The mechanism and therapeutic potential of lncRNA MIR497HG/miR-16-5p axis in breast cancer
od: Quan Cheng, et al.
Izdano: (2024-07-01)

ARHGAP6 Suppresses Breast Cancer Tumor Growth by Promoting Ferroptosis via RhoA-ROCK1-p38 MAPK Signaling
od: Xiaoqing Chen, et al.
Izdano: (2024-01-01)

MYST2 histone acetyltransferase promotes lung adenocarcinoma progression by regulating the p38 MAPK signaling pathway
od: Zhiang Huang, et al.
Izdano: (2025-01-01)

LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p/SPP1 axis
od: Hanbo Ma, et al.
Izdano: (2024-07-01)

Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer [Retraction]
od: Wei W, et al.
Izdano: (2024-08-01)

Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition
od: Ken’ichiro Hayashi, et al.
Izdano: (2023-10-01)

Curcumin Alleviates Osteoarthritis Through the p38MAPK Pathway: Network Pharmacological Prediction and Experimental Confirmation
od: Wang X, et al.
Izdano: (2024-07-01)

Molecular and Cellular Mechanisms of Electronegative Lipoproteins in Cardiovascular Diseases
od: Liang-Yin Ke, et al.
Izdano: (2020-11-01)

lncRNA ANCR regulating the effects of miR-497-5p on vascular lumen formation and apoptosis of gastric cancer cells
od: ZHU Tingting, XIA Yihan, SUN Shasha, GAO Peng, QIU Wensheng
Izdano: (2024-02-01)

Homoharringtonine enhances cytarabine-induced apoptosis in acute myeloid leukaemia by regulating the p38 MAPK/H2AX/Mcl-1 axis
od: Yang Qiu, et al.
Izdano: (2024-04-01)