Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town [version 4; peer review: 2 approved]
Tuberculosis (TB), caused by the highly infectious Mycobacterium tuberculosis, remains a leading cause of death worldwide, with an estimated 1.6 million associated deaths reported in 2017. In South Africa, an estimated 322,000 (range 230,000-428,000) people were infected with TB in 2017, and a quart...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2020-05-01
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| Series: | Gates Open Research |
| Online Access: | https://gatesopenresearch.org/articles/3-1491/v4 |
| _version_ | 1819206981390434304 |
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| author | Sabelo Hadebe Melissa Chengalroyen Reto Guler Kehilwe Nakedi Anastasia Koch Mohau Makatsa Muki Shey Suraj P. Parihar Bryan Bryson Mohlopheni J. Marakalala Hlumani Ndlovu |
| author_facet | Sabelo Hadebe Melissa Chengalroyen Reto Guler Kehilwe Nakedi Anastasia Koch Mohau Makatsa Muki Shey Suraj P. Parihar Bryan Bryson Mohlopheni J. Marakalala Hlumani Ndlovu |
| author_sort | Sabelo Hadebe |
| collection | DOAJ |
| description | Tuberculosis (TB), caused by the highly infectious Mycobacterium tuberculosis, remains a leading cause of death worldwide, with an estimated 1.6 million associated deaths reported in 2017. In South Africa, an estimated 322,000 (range 230,000-428,000) people were infected with TB in 2017, and a quarter of them lost their lives due to the disease. Bacille Calmette-Guérin (BCG) remains the only effective vaccine against disseminated TB, but its inability to confer complete protection against pulmonary TB in adolescents and adults calls for an urgent need to develop new and better vaccines. There is also a need to identify markers of disease protection and develop novel drugs. It is within this backdrop that we convened a nanosymposium at the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town to commemorate World TB Day and showcase recent findings generated by early career scientists in the institute. The speakers spoke on four broad topics: identification of novel drug targets, development of host-directed drug therapies, transmission of TB and immunology of TB/HIV co-infections. |
| first_indexed | 2024-12-23T05:16:14Z |
| format | Article |
| id | doaj.art-11ac7634b8634ce6b12666ffcb299cfd |
| institution | Directory Open Access Journal |
| issn | 2572-4754 |
| language | English |
| last_indexed | 2024-12-23T05:16:14Z |
| publishDate | 2020-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | Gates Open Research |
| spelling | doaj.art-11ac7634b8634ce6b12666ffcb299cfd2022-12-21T17:58:49ZengF1000 Research LtdGates Open Research2572-47542020-05-01310.12688/gatesopenres.13035.414333Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town [version 4; peer review: 2 approved]Sabelo Hadebe0Melissa Chengalroyen1Reto Guler2Kehilwe Nakedi3Anastasia Koch4Mohau Makatsa5Muki Shey6Suraj P. Parihar7Bryan Bryson8Mohlopheni J. Marakalala9Hlumani Ndlovu10Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine (IDM), Cape Town, Westen Cape, 7925, South AfricaSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Molecular Mycobacteriology unit, Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine based (IDM), University of Cape Town, Cape Town, Western Cape, 7925, South AfricaDivision of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine (IDM), Cape Town, Westen Cape, 7925, South AfricaDivision of Chemical and Systems Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, Western Cape, 7925, South AfricaSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Molecular Mycobacteriology unit, Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine based (IDM), University of Cape Town, Cape Town, Western Cape, 7925, South AfricaDivision of Medical Virology, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, Westen Cape, 7925, South AfricaWellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM) & Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, 7925, South AfricaWellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM) & Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, 7925, South AfricaMIT Biological Engineering, Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, MA 02142, USAAfrica Health Research Institute, South Africa, Durban, KwaZulu Natal, South AfricaDivision of Chemical and Systems Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, Western Cape, 7925, South AfricaTuberculosis (TB), caused by the highly infectious Mycobacterium tuberculosis, remains a leading cause of death worldwide, with an estimated 1.6 million associated deaths reported in 2017. In South Africa, an estimated 322,000 (range 230,000-428,000) people were infected with TB in 2017, and a quarter of them lost their lives due to the disease. Bacille Calmette-Guérin (BCG) remains the only effective vaccine against disseminated TB, but its inability to confer complete protection against pulmonary TB in adolescents and adults calls for an urgent need to develop new and better vaccines. There is also a need to identify markers of disease protection and develop novel drugs. It is within this backdrop that we convened a nanosymposium at the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town to commemorate World TB Day and showcase recent findings generated by early career scientists in the institute. The speakers spoke on four broad topics: identification of novel drug targets, development of host-directed drug therapies, transmission of TB and immunology of TB/HIV co-infections.https://gatesopenresearch.org/articles/3-1491/v4 |
| spellingShingle | Sabelo Hadebe Melissa Chengalroyen Reto Guler Kehilwe Nakedi Anastasia Koch Mohau Makatsa Muki Shey Suraj P. Parihar Bryan Bryson Mohlopheni J. Marakalala Hlumani Ndlovu Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town [version 4; peer review: 2 approved] Gates Open Research |
| title | Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town [version 4; peer review: 2 approved] |
| title_full | Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town [version 4; peer review: 2 approved] |
| title_fullStr | Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town [version 4; peer review: 2 approved] |
| title_full_unstemmed | Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town [version 4; peer review: 2 approved] |
| title_short | Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town [version 4; peer review: 2 approved] |
| title_sort | intervening along the spectrum of tuberculosis meeting report from the world tb day nanosymposium in the institute of infectious disease and molecular medicine at the university of cape town version 4 peer review 2 approved |
| url | https://gatesopenresearch.org/articles/3-1491/v4 |
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