Intact neural and behavioral correlates of emotion processing and regulation in weight-recovered anorexia nervosa: a combined fMRI and EMA study
Abstract Altered emotion processing and regulation mechanisms play a key role in eating disorders. We recently reported increased fMRI responses in brain regions involved in emotion processing (amygdala, dorsolateral prefrontal cortex) in acutely underweight anorexia nervosa (AN) patients while pass...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-01-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-01797-1 |
| _version_ | 1818300282290831360 |
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| author | Maria Seidel Sophie Pauligk Sophia Fürtjes Joseph A. King Sophie-Maleen Schlief Daniel Geisler Henrik Walter Thomas Goschke Stefan Ehrlich |
| author_facet | Maria Seidel Sophie Pauligk Sophia Fürtjes Joseph A. King Sophie-Maleen Schlief Daniel Geisler Henrik Walter Thomas Goschke Stefan Ehrlich |
| author_sort | Maria Seidel |
| collection | DOAJ |
| description | Abstract Altered emotion processing and regulation mechanisms play a key role in eating disorders. We recently reported increased fMRI responses in brain regions involved in emotion processing (amygdala, dorsolateral prefrontal cortex) in acutely underweight anorexia nervosa (AN) patients while passively viewing negatively valenced images. We also showed that patients’ ability to downregulate activity elicited by positively valenced pictures in a brain region involved in reward processing (ventral striatum) was predictive of worse outcomes (increased rumination and negative affect). The current study tries to answer the question of whether these alterations are only state effects associated with undernutrition or whether they constitute a trait characteristic of the disorder that persists after recovery. Forty-one individuals that were weight-recovered from AN (recAN) and 41 age-matched healthy controls (HC) completed an established emotion regulation paradigm using negatively and positively valenced visual stimuli. We assessed behavioral (arousal) and fMRI measures (activity in the amygdala, ventral striatum, and dorsolateral prefrontal cortex) during emotion processing and regulation. Additionally, measures of disorder-relevant rumination and affect were collected several times daily for 2 weeks after scanning via ecological momentary assessment. In contrast to our previous findings in acute AN patients, recAN showed no significant alterations either on a behavioral or neural level. Further, there were no associations between fMRI responses and post-scan momentary measures of rumination and affect. Together, these results suggest that neural responses to emotionally valenced stimuli as well as relationships with everyday rumination and affect likely reflect state-related alterations in AN that improve following successful weight-recovery. |
| first_indexed | 2024-12-13T05:04:38Z |
| format | Article |
| id | doaj.art-11adb2b9f5c544d3b0a0d2c3873e2b92 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-12-13T05:04:38Z |
| publishDate | 2022-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-11adb2b9f5c544d3b0a0d2c3873e2b922022-12-21T23:58:42ZengNature Publishing GroupTranslational Psychiatry2158-31882022-01-011211710.1038/s41398-022-01797-1Intact neural and behavioral correlates of emotion processing and regulation in weight-recovered anorexia nervosa: a combined fMRI and EMA studyMaria Seidel0Sophie Pauligk1Sophia Fürtjes2Joseph A. King3Sophie-Maleen Schlief4Daniel Geisler5Henrik Walter6Thomas Goschke7Stefan Ehrlich8Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität DresdenDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität DresdenDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität DresdenDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität DresdenDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität DresdenDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität DresdenDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité Universitätsmedizin BerlinDepartment of Psychology, Technische Universität DresdenDivision of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität DresdenAbstract Altered emotion processing and regulation mechanisms play a key role in eating disorders. We recently reported increased fMRI responses in brain regions involved in emotion processing (amygdala, dorsolateral prefrontal cortex) in acutely underweight anorexia nervosa (AN) patients while passively viewing negatively valenced images. We also showed that patients’ ability to downregulate activity elicited by positively valenced pictures in a brain region involved in reward processing (ventral striatum) was predictive of worse outcomes (increased rumination and negative affect). The current study tries to answer the question of whether these alterations are only state effects associated with undernutrition or whether they constitute a trait characteristic of the disorder that persists after recovery. Forty-one individuals that were weight-recovered from AN (recAN) and 41 age-matched healthy controls (HC) completed an established emotion regulation paradigm using negatively and positively valenced visual stimuli. We assessed behavioral (arousal) and fMRI measures (activity in the amygdala, ventral striatum, and dorsolateral prefrontal cortex) during emotion processing and regulation. Additionally, measures of disorder-relevant rumination and affect were collected several times daily for 2 weeks after scanning via ecological momentary assessment. In contrast to our previous findings in acute AN patients, recAN showed no significant alterations either on a behavioral or neural level. Further, there were no associations between fMRI responses and post-scan momentary measures of rumination and affect. Together, these results suggest that neural responses to emotionally valenced stimuli as well as relationships with everyday rumination and affect likely reflect state-related alterations in AN that improve following successful weight-recovery.https://doi.org/10.1038/s41398-022-01797-1 |
| spellingShingle | Maria Seidel Sophie Pauligk Sophia Fürtjes Joseph A. King Sophie-Maleen Schlief Daniel Geisler Henrik Walter Thomas Goschke Stefan Ehrlich Intact neural and behavioral correlates of emotion processing and regulation in weight-recovered anorexia nervosa: a combined fMRI and EMA study Translational Psychiatry |
| title | Intact neural and behavioral correlates of emotion processing and regulation in weight-recovered anorexia nervosa: a combined fMRI and EMA study |
| title_full | Intact neural and behavioral correlates of emotion processing and regulation in weight-recovered anorexia nervosa: a combined fMRI and EMA study |
| title_fullStr | Intact neural and behavioral correlates of emotion processing and regulation in weight-recovered anorexia nervosa: a combined fMRI and EMA study |
| title_full_unstemmed | Intact neural and behavioral correlates of emotion processing and regulation in weight-recovered anorexia nervosa: a combined fMRI and EMA study |
| title_short | Intact neural and behavioral correlates of emotion processing and regulation in weight-recovered anorexia nervosa: a combined fMRI and EMA study |
| title_sort | intact neural and behavioral correlates of emotion processing and regulation in weight recovered anorexia nervosa a combined fmri and ema study |
| url | https://doi.org/10.1038/s41398-022-01797-1 |
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