Role of Angiogenesis in the Pathogenesis of NAFLD
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, exposing to the risk of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Angio-genesis is a complex process leading to the development of new vessels from pre-existing vessels. Angiogenesis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/7/1338 |
| _version_ | 1797540204309905408 |
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| author | Lin Lei Haquima EI Mourabit Chantal Housset Axelle Cadoret Sara Lemoinne |
| author_facet | Lin Lei Haquima EI Mourabit Chantal Housset Axelle Cadoret Sara Lemoinne |
| author_sort | Lin Lei |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, exposing to the risk of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Angio-genesis is a complex process leading to the development of new vessels from pre-existing vessels. Angiogenesis is triggered by hypoxia and inflammation and is driven by the action of proangiogenic cytokines, mainly vascular endothelial growth factor (VEGF). In this review, we focus on liver angiogenesis associated with NAFLD and analyze the evidence of liver angiogenesis in animal models of NAFLD and in NAFLD patients. We also report the data explaining the role of angiogenesis in the progression of NAFLD and discuss the potential of targeting angiogenesis, notably VEGF, to treat NAFLD. |
| first_indexed | 2024-03-10T12:56:45Z |
| format | Article |
| id | doaj.art-11ae40d997b746b8be36530fe3cd4046 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:56:45Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-11ae40d997b746b8be36530fe3cd40462023-11-21T11:48:12ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01107133810.3390/jcm10071338Role of Angiogenesis in the Pathogenesis of NAFLDLin Lei0Haquima EI Mourabit1Chantal Housset2Axelle Cadoret3Sara Lemoinne4Centre de Recherche Saint-Antoine (CRSA) and Institute of Cardiometabolism and Nutrition (ICAN), Sorbonne Université, INSERM, 75012 Paris, FranceCentre de Recherche Saint-Antoine (CRSA) and Institute of Cardiometabolism and Nutrition (ICAN), Sorbonne Université, INSERM, 75012 Paris, FranceCentre de Recherche Saint-Antoine (CRSA) and Institute of Cardiometabolism and Nutrition (ICAN), Sorbonne Université, INSERM, 75012 Paris, FranceCentre de Recherche Saint-Antoine (CRSA) and Institute of Cardiometabolism and Nutrition (ICAN), Sorbonne Université, INSERM, 75012 Paris, FranceCentre de Recherche Saint-Antoine (CRSA) and Institute of Cardiometabolism and Nutrition (ICAN), Sorbonne Université, INSERM, 75012 Paris, FranceNon-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, exposing to the risk of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Angio-genesis is a complex process leading to the development of new vessels from pre-existing vessels. Angiogenesis is triggered by hypoxia and inflammation and is driven by the action of proangiogenic cytokines, mainly vascular endothelial growth factor (VEGF). In this review, we focus on liver angiogenesis associated with NAFLD and analyze the evidence of liver angiogenesis in animal models of NAFLD and in NAFLD patients. We also report the data explaining the role of angiogenesis in the progression of NAFLD and discuss the potential of targeting angiogenesis, notably VEGF, to treat NAFLD.https://www.mdpi.com/2077-0383/10/7/1338non-alcoholic steatohepatitisliver sinusoidal endothelial cellsvascular endothelial growth factor |
| spellingShingle | Lin Lei Haquima EI Mourabit Chantal Housset Axelle Cadoret Sara Lemoinne Role of Angiogenesis in the Pathogenesis of NAFLD Journal of Clinical Medicine non-alcoholic steatohepatitis liver sinusoidal endothelial cells vascular endothelial growth factor |
| title | Role of Angiogenesis in the Pathogenesis of NAFLD |
| title_full | Role of Angiogenesis in the Pathogenesis of NAFLD |
| title_fullStr | Role of Angiogenesis in the Pathogenesis of NAFLD |
| title_full_unstemmed | Role of Angiogenesis in the Pathogenesis of NAFLD |
| title_short | Role of Angiogenesis in the Pathogenesis of NAFLD |
| title_sort | role of angiogenesis in the pathogenesis of nafld |
| topic | non-alcoholic steatohepatitis liver sinusoidal endothelial cells vascular endothelial growth factor |
| url | https://www.mdpi.com/2077-0383/10/7/1338 |
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