MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, s...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25325-9 |
| _version_ | 1819194816902201344 |
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| author | C. Kalogirou J. Linxweiler P. Schmucker M. T. Snaebjornsson W. Schmitz S. Wach M. Krebs E. Hartmann M. Puhr A. Müller M. Spahn A. K. Seitz T. Frank H. Marouf G. Büchel M. Eckstein H. Kübler M. Eilers M. Saar K. Junker F. Röhrig B. Kneitz M. T. Rosenfeldt A. Schulze |
| author_facet | C. Kalogirou J. Linxweiler P. Schmucker M. T. Snaebjornsson W. Schmitz S. Wach M. Krebs E. Hartmann M. Puhr A. Müller M. Spahn A. K. Seitz T. Frank H. Marouf G. Büchel M. Eckstein H. Kübler M. Eilers M. Saar K. Junker F. Röhrig B. Kneitz M. T. Rosenfeldt A. Schulze |
| author_sort | C. Kalogirou |
| collection | DOAJ |
| description | Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, squalene epoxidase. |
| first_indexed | 2024-12-23T02:02:53Z |
| format | Article |
| id | doaj.art-11b1a821ae93404d9aff913722f3970e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:02:53Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-11b1a821ae93404d9aff913722f3970e2022-12-21T18:03:56ZengNature PortfolioNature Communications2041-17232021-08-0112112010.1038/s41467-021-25325-9MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancerC. Kalogirou0J. Linxweiler1P. Schmucker2M. T. Snaebjornsson3W. Schmitz4S. Wach5M. Krebs6E. Hartmann7M. Puhr8A. Müller9M. Spahn10A. K. Seitz11T. Frank12H. Marouf13G. Büchel14M. Eckstein15H. Kübler16M. Eilers17M. Saar18K. Junker19F. Röhrig20B. Kneitz21M. T. Rosenfeldt22A. Schulze23Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, BiocenterDepartment of Urology, Saarland UniversityDepartment of Urology and Paediatric Urology, University Hospital WürzburgGerman Cancer Research Center, Division of Tumor Metabolism and MicroenvironmentDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, BiocenterDepartment of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-NurembergDepartment of Urology and Paediatric Urology, University Hospital WürzburgInstitute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) MainfrankenDepartment of Urology, Medical University of InnsbruckClinic for Diagnostic and Interventional Radiology, Saarland UniversityCenter for Urology, Hirslanden Private Hospital GroupDepartment of Urology and Paediatric Urology, University Hospital WürzburgDepartment of Urology and Paediatric Urology, University Hospital WürzburgDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, BiocenterDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, BiocenterInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-NurembergDepartment of Urology and Paediatric Urology, University Hospital WürzburgDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, BiocenterDepartment of Urology, Saarland UniversityDepartment of Urology, Saarland UniversityDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, BiocenterDepartment of Urology and Paediatric Urology, University Hospital WürzburgInstitute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) MainfrankenDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, BiocenterCholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, squalene epoxidase.https://doi.org/10.1038/s41467-021-25325-9 |
| spellingShingle | C. Kalogirou J. Linxweiler P. Schmucker M. T. Snaebjornsson W. Schmitz S. Wach M. Krebs E. Hartmann M. Puhr A. Müller M. Spahn A. K. Seitz T. Frank H. Marouf G. Büchel M. Eckstein H. Kübler M. Eilers M. Saar K. Junker F. Röhrig B. Kneitz M. T. Rosenfeldt A. Schulze MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer Nature Communications |
| title | MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer |
| title_full | MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer |
| title_fullStr | MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer |
| title_full_unstemmed | MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer |
| title_short | MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer |
| title_sort | mir 205 driven downregulation of cholesterol biosynthesis through sqle inhibition identifies therapeutic vulnerability in aggressive prostate cancer |
| url | https://doi.org/10.1038/s41467-021-25325-9 |
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