Functional Screening of Parkinson’s Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegans

Functional Screening of Parkinson’s Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegans

Idiopathic Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic (DA) neurons during aging. The pathological hallmark of PD is the Lewy body detected in postmortem brain tissue, which is mainly composed of aggregated α-Synuclein (αSyn). However, it is estimated that 90% of PD...

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Bibliographic Details
Main Authors:	Roman Vozdek, Peter P. Pramstaller, Andrew A. Hicks
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Series:	Frontiers in Aging Neuroscience
Subjects:	Parkinson’s disease α-synuclein GWAS neurodegeneration genetic screen C. elegans
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.806000/full

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