Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversies
Soft tissue sarcomas (STSs) are an uncommon and diverse group of more than 50 mesenchymal malignancies. Each of these histologic subtypes represents a unique disease with distinct biologic behavior and varying sensitivity to chemotherapy. The judicious use of adjuvant/neoadjuvant chemotherapy along...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2016-01-01
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| Series: | South Asian Journal of Cancer |
| Subjects: | |
| Online Access: | http://journal.sajc.org/article.asp?issn=2278-330X;year=2016;volume=5;issue=1;spage=15;epage=19;aulast=Bajpai |
| _version_ | 1818656318685184000 |
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| author | Jyoti Bajpai Deepa Susan |
| author_facet | Jyoti Bajpai Deepa Susan |
| author_sort | Jyoti Bajpai |
| collection | DOAJ |
| description | Soft tissue sarcomas (STSs) are an uncommon and diverse group of more than 50 mesenchymal malignancies. Each of these histologic subtypes represents a unique disease with distinct biologic behavior and varying sensitivity to chemotherapy. The judicious use of adjuvant/neoadjuvant chemotherapy along with surgery and radiation in the treatment of localized STS has a role in improving patient outcomes by decreasing local and distant recurrences. There is evidence that the use of adjuvant chemotherapy to a mixed cohort of chemo sensitive and insensitive sarcoma subtypes results in limited benefit. Therefore, it is of paramount importance to identify the subpopulation with high metastatic potential and to identify effective histology-specific treatment options to these patients. Present perspective, will focus on the rationale for adjuvant chemotherapy in sarcoma, with emphasis on the histology driven chemotherapy. It will outline key therapeutic opportunities and hurdles in adjuvant medical treatment of sarcoma, focusing on specific subtypes that are on the verge of new breakthroughs, as well as those in which promise has not lived up to expectations. |
| first_indexed | 2024-12-17T03:23:41Z |
| format | Article |
| id | doaj.art-11b4103016624604826a8bcab72a24b2 |
| institution | Directory Open Access Journal |
| issn | 2278-330X 2278-4306 |
| language | English |
| last_indexed | 2024-12-17T03:23:41Z |
| publishDate | 2016-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-11b4103016624604826a8bcab72a24b22022-12-21T22:05:27ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062016-01-0151151910.4103/2278-330X.179687Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversiesJyoti BajpaiDeepa SusanSoft tissue sarcomas (STSs) are an uncommon and diverse group of more than 50 mesenchymal malignancies. Each of these histologic subtypes represents a unique disease with distinct biologic behavior and varying sensitivity to chemotherapy. The judicious use of adjuvant/neoadjuvant chemotherapy along with surgery and radiation in the treatment of localized STS has a role in improving patient outcomes by decreasing local and distant recurrences. There is evidence that the use of adjuvant chemotherapy to a mixed cohort of chemo sensitive and insensitive sarcoma subtypes results in limited benefit. Therefore, it is of paramount importance to identify the subpopulation with high metastatic potential and to identify effective histology-specific treatment options to these patients. Present perspective, will focus on the rationale for adjuvant chemotherapy in sarcoma, with emphasis on the histology driven chemotherapy. It will outline key therapeutic opportunities and hurdles in adjuvant medical treatment of sarcoma, focusing on specific subtypes that are on the verge of new breakthroughs, as well as those in which promise has not lived up to expectations.http://journal.sajc.org/article.asp?issn=2278-330X;year=2016;volume=5;issue=1;spage=15;epage=19;aulast=BajpaiAdjuvant chemotherapy options, chemosensitive histologies, consensus, controversies, soft tissue sarcoma |
| spellingShingle | Jyoti Bajpai Deepa Susan Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversies South Asian Journal of Cancer Adjuvant chemotherapy options, chemosensitive histologies, consensus, controversies, soft tissue sarcoma |
| title | Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversies |
| title_full | Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversies |
| title_fullStr | Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversies |
| title_full_unstemmed | Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversies |
| title_short | Adjuvant chemotherapy in soft tissue sarcomas…Conflicts, consensus, and controversies |
| title_sort | adjuvant chemotherapy in soft tissue sarcomas conflicts consensus and controversies |
| topic | Adjuvant chemotherapy options, chemosensitive histologies, consensus, controversies, soft tissue sarcoma |
| url | http://journal.sajc.org/article.asp?issn=2278-330X;year=2016;volume=5;issue=1;spage=15;epage=19;aulast=Bajpai |
| work_keys_str_mv | AT jyotibajpai adjuvantchemotherapyinsofttissuesarcomasconflictsconsensusandcontroversies AT deepasusan adjuvantchemotherapyinsofttissuesarcomasconflictsconsensusandcontroversies |