A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup
Empiric anti-tuberculous therapy should not be delayed in patients with a strong clinical suspicion for TB. Because confirmatory TB testing may be difficult to obtain, early and empiric treatment, when there is concern for central nervous system TB, may result in improved outcomes for patients. Gene...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00430/full |
| _version_ | 1819012134675152896 |
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| author | Adeel S. Zubair Mark Landreneau Jens Witsch Robert K. Fulbright Anita Huttner Kevin N. Sheth Kevin N. Sheth David Y. Hwang David Y. Hwang |
| author_facet | Adeel S. Zubair Mark Landreneau Jens Witsch Robert K. Fulbright Anita Huttner Kevin N. Sheth Kevin N. Sheth David Y. Hwang David Y. Hwang |
| author_sort | Adeel S. Zubair |
| collection | DOAJ |
| description | Empiric anti-tuberculous therapy should not be delayed in patients with a strong clinical suspicion for TB. Because confirmatory TB testing may be difficult to obtain, early and empiric treatment, when there is concern for central nervous system TB, may result in improved outcomes for patients. GeneXpert is currently an area of active research, and the test returns diagnostic results within hours, which would make it the preferred test for investigating TB meningitis. |
| first_indexed | 2024-12-21T01:39:14Z |
| format | Article |
| id | doaj.art-11b427bd117d4494916be890e81c573d |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T01:39:14Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-11b427bd117d4494916be890e81c573d2022-12-21T19:20:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00430535580A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial WorkupAdeel S. Zubair0Mark Landreneau1Jens Witsch2Robert K. Fulbright3Anita Huttner4Kevin N. Sheth5Kevin N. Sheth6David Y. Hwang7David Y. Hwang8Department of Neurology, Yale School of Medicine, New Haven, CT, United StatesDepartment of Neurology, Stamford Hospital, Stamford, CT, United StatesDepartment of Neurology, Yale School of Medicine, New Haven, CT, United StatesDepartment of Radiology, Yale School of Medicine, New Haven, CT, United StatesDepartment of Pathology, Yale School of Medicine, New Haven, CT, United StatesDepartment of Neurology, Yale School of Medicine, New Haven, CT, United StatesDivision of Neurocritical Care and Emergency Neurology, Yale School of Medicine, New Haven, CT, United StatesDepartment of Neurology, Yale School of Medicine, New Haven, CT, United StatesDivision of Neurocritical Care and Emergency Neurology, Yale School of Medicine, New Haven, CT, United StatesEmpiric anti-tuberculous therapy should not be delayed in patients with a strong clinical suspicion for TB. Because confirmatory TB testing may be difficult to obtain, early and empiric treatment, when there is concern for central nervous system TB, may result in improved outcomes for patients. GeneXpert is currently an area of active research, and the test returns diagnostic results within hours, which would make it the preferred test for investigating TB meningitis.https://www.frontiersin.org/article/10.3389/fneur.2020.00430/fullCNS TBtuberculosisleptomeningeal enhancementGeneXpertMeningitis |
| spellingShingle | Adeel S. Zubair Mark Landreneau Jens Witsch Robert K. Fulbright Anita Huttner Kevin N. Sheth Kevin N. Sheth David Y. Hwang David Y. Hwang A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup Frontiers in Neurology CNS TB tuberculosis leptomeningeal enhancement GeneXpert Meningitis |
| title | A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup |
| title_full | A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup |
| title_fullStr | A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup |
| title_full_unstemmed | A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup |
| title_short | A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup |
| title_sort | critically ill patient with central nervous system tuberculosis and negative initial workup |
| topic | CNS TB tuberculosis leptomeningeal enhancement GeneXpert Meningitis |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00430/full |
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