ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability

ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability

Abstract Background Impaired wound re-epithelialization contributes to cutaneous barrier reconstruction dysfunction. Recently, N 6-methyladenosine (m6A) RNA modification has been shown to participate in the determination of RNA fate, and its aberration triggers the pathogenesis of numerous diseases....

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Main Authors: Xin Huang, Yixuan Zhao, Daiming Liu, Shuchen Gu, Yunhan Liu, Yimin Khoong, Shenying Luo, Zewei Zhang, Wenzheng Xia, Meng Wang, Hsin Liang, Minxiong Li, Qingfeng Li, Tao Zan
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Inflammation and Regeneration
Subjects:
N 6-Methyladenosine (m6a) RNA modification
ALKBH5
Re-epithelialization
PELI2
RNA stability
Online Access:https://doi.org/10.1186/s41232-023-00288-0

Internet

https://doi.org/10.1186/s41232-023-00288-0

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