Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report
Hepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly eff...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2016-10-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/450679 |
| _version_ | 1811239129449496576 |
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| author | Kenji Misaka Takashi Kishimoto Yuji Kawahigashi Michio Sata Yumiko Nagao |
| author_facet | Kenji Misaka Takashi Kishimoto Yuji Kawahigashi Michio Sata Yumiko Nagao |
| author_sort | Kenji Misaka |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly effective and safe for the eradication of HCV. However, there is a lack of information regarding the association between HCV-associated OLP and interferon (IFN)-free DAA therapy. Herein, we present the case of a 60-year-old female who was diagnosed with OLP during routine periodontal treatment by a dentist. The patient was referred for hepatitis C treatment using IFN-free DAA, which resulted in the improvement of the symptoms of OLP. This case represents the safety and efficacy of IFN-free DAAs in patients with HCV-associated OLP. However, long-term follow-up studies are required to elucidate the therapeutic effects of this therapy in these patients. |
| first_indexed | 2024-04-12T12:54:26Z |
| format | Article |
| id | doaj.art-11b80be2c3bf4391a925400fc10fd46c |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-12T12:54:26Z |
| publishDate | 2016-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-11b80be2c3bf4391a925400fc10fd46c2022-12-22T03:32:22ZengKarger PublishersCase Reports in Gastroenterology1662-06312016-10-0110361762210.1159/000450679450679Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case ReportKenji MisakaTakashi KishimotoYuji KawahigashiMichio SataYumiko NagaoHepatitis C virus (HCV) is frequently associated with various extrahepatic manifestations such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one of the representative extrahepatic manifestations of HCV infection. Direct-acting antivirals (DAA) are highly effective and safe for the eradication of HCV. However, there is a lack of information regarding the association between HCV-associated OLP and interferon (IFN)-free DAA therapy. Herein, we present the case of a 60-year-old female who was diagnosed with OLP during routine periodontal treatment by a dentist. The patient was referred for hepatitis C treatment using IFN-free DAA, which resulted in the improvement of the symptoms of OLP. This case represents the safety and efficacy of IFN-free DAAs in patients with HCV-associated OLP. However, long-term follow-up studies are required to elucidate the therapeutic effects of this therapy in these patients.http://www.karger.com/Article/FullText/450679InterferonDirect-acting antiviralsExtrahepatic manifestationsHepatitis C virusOral lichen planus |
| spellingShingle | Kenji Misaka Takashi Kishimoto Yuji Kawahigashi Michio Sata Yumiko Nagao Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report Case Reports in Gastroenterology Interferon Direct-acting antivirals Extrahepatic manifestations Hepatitis C virus Oral lichen planus |
| title | Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report |
| title_full | Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report |
| title_fullStr | Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report |
| title_full_unstemmed | Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report |
| title_short | Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report |
| title_sort | use of direct acting antivirals for the treatment of hepatitis c virus associated oral lichen planus a case report |
| topic | Interferon Direct-acting antivirals Extrahepatic manifestations Hepatitis C virus Oral lichen planus |
| url | http://www.karger.com/Article/FullText/450679 |
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