Role of hypothyroidism in dyslipidemia and blood glucose regulation.
Context: Overt hypothyroidism is an established risk factor for insulin resistance and hyperlipidemia Aims: To evaluate the role of thyroid dysfunction on alteration of glucose and lipid metabolism leading to insulin resistance, an important risk factor for cardio vascular diseases. Setting and...
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| Format: | Article |
| Language: | English |
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Prathima Institute of Medical Sciences
2019-08-01
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| Series: | Perspectives In Medical Research |
| Subjects: | |
| Online Access: | http://www.pimr.org.in/2019-vol7-issue-2/ushakiran_v2.PDF |
| Summary: | Context: Overt hypothyroidism is an established risk
factor for insulin resistance and hyperlipidemia
Aims: To evaluate the role of thyroid dysfunction on
alteration of glucose and lipid metabolism leading to insulin
resistance, an important risk factor for cardio vascular diseases.
Setting and Design: In this study we included 50
subjects, aged 25 to 35 years. This is a case control study
conducted in department of Biochemistry.
Materials & Methods: Investigations like fasting and
post prandial blood sugar, HbA1c and lipid profile (Cholesterol,
Triglycerides, HDL, LDL & VLDL) were done. Blood pressure was
measured. Body weight and height were measured and BMI
was calculated. All the parameters were analyzed using XL 640
fully automated random access analyzer.
Statistical analysis used: tudent t test was used using
graph pad quickcalcs software.
Results: The cases were selected based on T4 and TSH
concentrations whose values were significantly decreased and
elevated respectively. The patients with hypothyroidism
exhibited significant increase in concentration of total
cholesterol, LDL, fasting blood glucose and HbA1c while HDL
(p<0.05) showed a decrease in its concentration in comparison
to controls. BMI and diastolic blood pressure showed significant
elevation in hypothyroid individuals when compared to
controls.
Conclusions:
It is evident from this study that insulin resistance bears
an indispensable role in connecting T2DM and thyroid
dysfunction. Cardiovascular events are the counter reflection
of resurgence of heavily disturbed lipid metabolism due to
thyroid dyscrasias. |
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| ISSN: | 2348-1447 2348-229X |