Role of hypothyroidism in dyslipidemia and blood glucose regulation.
Context: Overt hypothyroidism is an established risk factor for insulin resistance and hyperlipidemia Aims: To evaluate the role of thyroid dysfunction on alteration of glucose and lipid metabolism leading to insulin resistance, an important risk factor for cardio vascular diseases. Setting and...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Prathima Institute of Medical Sciences
2019-08-01
|
| Series: | Perspectives In Medical Research |
| Subjects: | |
| Online Access: | http://www.pimr.org.in/2019-vol7-issue-2/ushakiran_v2.PDF |
| _version_ | 1797462432191348736 |
|---|---|
| author | Usha kiran P1 , Sandeesha V2 ,Lakshmana kumar N,3 |
| author_facet | Usha kiran P1 , Sandeesha V2 ,Lakshmana kumar N,3 |
| author_sort | Usha kiran P1 , Sandeesha V2 ,Lakshmana kumar N,3 |
| collection | DOAJ |
| description | Context: Overt hypothyroidism is an established risk
factor for insulin resistance and hyperlipidemia
Aims: To evaluate the role of thyroid dysfunction on
alteration of glucose and lipid metabolism leading to insulin
resistance, an important risk factor for cardio vascular diseases.
Setting and Design: In this study we included 50
subjects, aged 25 to 35 years. This is a case control study
conducted in department of Biochemistry.
Materials & Methods: Investigations like fasting and
post prandial blood sugar, HbA1c and lipid profile (Cholesterol,
Triglycerides, HDL, LDL & VLDL) were done. Blood pressure was
measured. Body weight and height were measured and BMI
was calculated. All the parameters were analyzed using XL 640
fully automated random access analyzer.
Statistical analysis used: tudent t test was used using
graph pad quickcalcs software.
Results: The cases were selected based on T4 and TSH
concentrations whose values were significantly decreased and
elevated respectively. The patients with hypothyroidism
exhibited significant increase in concentration of total
cholesterol, LDL, fasting blood glucose and HbA1c while HDL
(p<0.05) showed a decrease in its concentration in comparison
to controls. BMI and diastolic blood pressure showed significant
elevation in hypothyroid individuals when compared to
controls.
Conclusions:
It is evident from this study that insulin resistance bears
an indispensable role in connecting T2DM and thyroid
dysfunction. Cardiovascular events are the counter reflection
of resurgence of heavily disturbed lipid metabolism due to
thyroid dyscrasias. |
| first_indexed | 2024-03-09T17:36:27Z |
| format | Article |
| id | doaj.art-11b81b2e85e44e10a41e2c87e6262a0e |
| institution | Directory Open Access Journal |
| issn | 2348-1447 2348-229X |
| language | English |
| last_indexed | 2024-03-09T17:36:27Z |
| publishDate | 2019-08-01 |
| publisher | Prathima Institute of Medical Sciences |
| record_format | Article |
| series | Perspectives In Medical Research |
| spelling | doaj.art-11b81b2e85e44e10a41e2c87e6262a0e2023-11-24T11:52:42ZengPrathima Institute of Medical SciencesPerspectives In Medical Research2348-14472348-229X2019-08-01725661Role of hypothyroidism in dyslipidemia and blood glucose regulation.Usha kiran P1 , Sandeesha V2 ,Lakshmana kumar N,30 RK HospitalContext: Overt hypothyroidism is an established risk factor for insulin resistance and hyperlipidemia Aims: To evaluate the role of thyroid dysfunction on alteration of glucose and lipid metabolism leading to insulin resistance, an important risk factor for cardio vascular diseases. Setting and Design: In this study we included 50 subjects, aged 25 to 35 years. This is a case control study conducted in department of Biochemistry. Materials & Methods: Investigations like fasting and post prandial blood sugar, HbA1c and lipid profile (Cholesterol, Triglycerides, HDL, LDL & VLDL) were done. Blood pressure was measured. Body weight and height were measured and BMI was calculated. All the parameters were analyzed using XL 640 fully automated random access analyzer. Statistical analysis used: tudent t test was used using graph pad quickcalcs software. Results: The cases were selected based on T4 and TSH concentrations whose values were significantly decreased and elevated respectively. The patients with hypothyroidism exhibited significant increase in concentration of total cholesterol, LDL, fasting blood glucose and HbA1c while HDL (p<0.05) showed a decrease in its concentration in comparison to controls. BMI and diastolic blood pressure showed significant elevation in hypothyroid individuals when compared to controls. Conclusions: It is evident from this study that insulin resistance bears an indispensable role in connecting T2DM and thyroid dysfunction. Cardiovascular events are the counter reflection of resurgence of heavily disturbed lipid metabolism due to thyroid dyscrasias.http://www.pimr.org.in/2019-vol7-issue-2/ushakiran_v2.PDFhypothyroidismlipid profileglycated hemoglobinblood pressure and bmi |
| spellingShingle | Usha kiran P1 , Sandeesha V2 ,Lakshmana kumar N,3 Role of hypothyroidism in dyslipidemia and blood glucose regulation. Perspectives In Medical Research hypothyroidism lipid profile glycated hemoglobin blood pressure and bmi |
| title | Role of hypothyroidism in dyslipidemia and blood glucose regulation. |
| title_full | Role of hypothyroidism in dyslipidemia and blood glucose regulation. |
| title_fullStr | Role of hypothyroidism in dyslipidemia and blood glucose regulation. |
| title_full_unstemmed | Role of hypothyroidism in dyslipidemia and blood glucose regulation. |
| title_short | Role of hypothyroidism in dyslipidemia and blood glucose regulation. |
| title_sort | role of hypothyroidism in dyslipidemia and blood glucose regulation |
| topic | hypothyroidism lipid profile glycated hemoglobin blood pressure and bmi |
| url | http://www.pimr.org.in/2019-vol7-issue-2/ushakiran_v2.PDF |
| work_keys_str_mv | AT ushakiranp1sandeeshav2lakshmanakumarn3 roleofhypothyroidismindyslipidemiaandbloodglucoseregulation |