Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens
Copper based metallo drugs were prepared and their antibacterial, antifungal, molecular mechanism of [Cu(SAla)Phen]·H2O and [Cu(SAla)bpy]·H2O complexes were investigated. The [Cu(SAla)Phen]·H2O and [Cu(SAla)bpy]·H2O were derived from the Schiff base alanine salicylaldehyde. [Cu(SAla)Phen]·H2O showed...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610311002456 |
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| author | S. Chandraleka K. Ramya G. Chandramohan D. Dhanasekaran A. Priyadharshini A. Panneerselvam |
| author_facet | S. Chandraleka K. Ramya G. Chandramohan D. Dhanasekaran A. Priyadharshini A. Panneerselvam |
| author_sort | S. Chandraleka |
| collection | DOAJ |
| description | Copper based metallo drugs were prepared and their antibacterial, antifungal, molecular mechanism of [Cu(SAla)Phen]·H2O and [Cu(SAla)bpy]·H2O complexes were investigated. The [Cu(SAla)Phen]·H2O and [Cu(SAla)bpy]·H2O were derived from the Schiff base alanine salicylaldehyde. [Cu(SAla)Phen]·H2O showed noteworthy antibacterial and antifungal activity than the [Cu(SAla)bpy]·H2O and ligand alanine, salicylaldehyde. The [Cu(SAla)Phen]·H2O complex showed significant antibacterial activity against Salmonella typhi, Staphylococcus aureus, Salmonella paratyphi and the antifungal activity against Candida albicans and Cryptococcus neoformans in well diffusion assay. The mode of action of copper (II) complex was analyzed by DNA cleavage activity and in silico molecular docking. The present findings provide important insight into the molecular mechanism of copper (II) complexes in susceptible bacterial and fungal pathogens. These results collectively support the use of [Cu(SAla)Phen]·H2O complex as a suitable drug to treat bacterial and fungal infections. |
| first_indexed | 2024-12-12T07:30:02Z |
| format | Article |
| id | doaj.art-11b871d9fecc4b7c87996f7c05d621d4 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-12T07:30:02Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-11b871d9fecc4b7c87996f7c05d621d42022-12-22T00:33:02ZengElsevierJournal of Saudi Chemical Society1319-61032014-12-0118695396210.1016/j.jscs.2011.11.020Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogensS. Chandraleka0K. Ramya1G. Chandramohan2D. Dhanasekaran3A. Priyadharshini4A. Panneerselvam5Department of Chemistry, A.V.V.M. Sri Pushpam College (Autonomous), Poondi 613 503, Thanjavur District, Tamil Nadu, IndiaDepartment of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirapalli 620 024, Tamil Nadu, IndiaDepartment of Chemistry, A.V.V.M. Sri Pushpam College (Autonomous), Poondi 613 503, Thanjavur District, Tamil Nadu, IndiaDepartment of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirapalli 620 024, Tamil Nadu, IndiaDepartment of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirapalli 620 024, Tamil Nadu, IndiaP.G. & Research Department of Botany & Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi 613 503, Thanjavur District, Tamil Nadu, IndiaCopper based metallo drugs were prepared and their antibacterial, antifungal, molecular mechanism of [Cu(SAla)Phen]·H2O and [Cu(SAla)bpy]·H2O complexes were investigated. The [Cu(SAla)Phen]·H2O and [Cu(SAla)bpy]·H2O were derived from the Schiff base alanine salicylaldehyde. [Cu(SAla)Phen]·H2O showed noteworthy antibacterial and antifungal activity than the [Cu(SAla)bpy]·H2O and ligand alanine, salicylaldehyde. The [Cu(SAla)Phen]·H2O complex showed significant antibacterial activity against Salmonella typhi, Staphylococcus aureus, Salmonella paratyphi and the antifungal activity against Candida albicans and Cryptococcus neoformans in well diffusion assay. The mode of action of copper (II) complex was analyzed by DNA cleavage activity and in silico molecular docking. The present findings provide important insight into the molecular mechanism of copper (II) complexes in susceptible bacterial and fungal pathogens. These results collectively support the use of [Cu(SAla)Phen]·H2O complex as a suitable drug to treat bacterial and fungal infections.http://www.sciencedirect.com/science/article/pii/S1319610311002456Copper (II) complexBacteriaFungiDNAMolecular docking |
| spellingShingle | S. Chandraleka K. Ramya G. Chandramohan D. Dhanasekaran A. Priyadharshini A. Panneerselvam Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens Journal of Saudi Chemical Society Copper (II) complex Bacteria Fungi DNA Molecular docking |
| title | Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens |
| title_full | Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens |
| title_fullStr | Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens |
| title_full_unstemmed | Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens |
| title_short | Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens |
| title_sort | antimicrobial mechanism of copper ii 1 10 phenanthroline and 2 2 bipyridyl complex on bacterial and fungal pathogens |
| topic | Copper (II) complex Bacteria Fungi DNA Molecular docking |
| url | http://www.sciencedirect.com/science/article/pii/S1319610311002456 |
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