Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer

Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer

Aspirin prevents cardiovascular disease and colon cancer; however aspirin's inhibition of platelet COX-1 only partially explains its diverse effects. We previously identified an aspirin response signature (ARS) in blood consisting of 62 co-expressed transcripts that correlated with aspirin'...

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Bibliographic Details
Main Authors: Deepak Voora, MD, A. Koneti Rao, MD, Gauthami S. Jalagadugula, PhD, Rachel Myers, PhD, Emily Harris, Thomas L. Ortel, MD, PhD, Geoffrey S. Ginsburg, MD, PhD
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:EBioMedicine
Subjects:
Aspirin
Systems pharmacogenomics
Cardiovascular disease
Colorectal cancer
Gene expression profiling
RUNX1
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641630370X

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