On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament
The spiral ligament in the cochlea has been suggested to play a significant role in the pathophysiology of different etiologies of strial hearing loss. Spiral ligament fibrocytes (SLFs), the main cell type in the lateral wall, are crucial in maintaining the endocochlear potential and regulating bloo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.580639/full |
| _version_ | 1818403790922973184 |
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| author | Noa Peeleman Dorien Verdoodt Dorien Verdoodt Peter Ponsaerts Vincent Van Rompaey Vincent Van Rompaey |
| author_facet | Noa Peeleman Dorien Verdoodt Dorien Verdoodt Peter Ponsaerts Vincent Van Rompaey Vincent Van Rompaey |
| author_sort | Noa Peeleman |
| collection | DOAJ |
| description | The spiral ligament in the cochlea has been suggested to play a significant role in the pathophysiology of different etiologies of strial hearing loss. Spiral ligament fibrocytes (SLFs), the main cell type in the lateral wall, are crucial in maintaining the endocochlear potential and regulating blood flow. SLF dysfunction can therefore cause cochlear dysfunction and thus hearing impairment. Recent studies have highlighted the role of SLFs in the immune response of the cochlea. In contrast to sensory cells in the inner ear, SLFs (more specifically type III fibrocytes) have also demonstrated the ability to regenerate after different types of trauma such as drug toxicity and noise. SLFs are responsible for producing proteins, such as collagen and cochlin, that create an adequate extracellular matrix to thrive in. Any dysfunction of SLFs or structural changes to the extracellular matrix can significantly impact hearing function. However, SLFs may prove useful in restoring hearing by their potential to regenerate cells in the spiral ligament. |
| first_indexed | 2024-12-14T08:29:52Z |
| format | Article |
| id | doaj.art-11b9e99dfbab402bbec2a0d750ccdd34 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T08:29:52Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-11b9e99dfbab402bbec2a0d750ccdd342022-12-21T23:09:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-10-011110.3389/fneur.2020.580639580639On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral LigamentNoa Peeleman0Dorien Verdoodt1Dorien Verdoodt2Peter Ponsaerts3Vincent Van Rompaey4Vincent Van Rompaey5Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumLaboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, BelgiumLaboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumThe spiral ligament in the cochlea has been suggested to play a significant role in the pathophysiology of different etiologies of strial hearing loss. Spiral ligament fibrocytes (SLFs), the main cell type in the lateral wall, are crucial in maintaining the endocochlear potential and regulating blood flow. SLF dysfunction can therefore cause cochlear dysfunction and thus hearing impairment. Recent studies have highlighted the role of SLFs in the immune response of the cochlea. In contrast to sensory cells in the inner ear, SLFs (more specifically type III fibrocytes) have also demonstrated the ability to regenerate after different types of trauma such as drug toxicity and noise. SLFs are responsible for producing proteins, such as collagen and cochlin, that create an adequate extracellular matrix to thrive in. Any dysfunction of SLFs or structural changes to the extracellular matrix can significantly impact hearing function. However, SLFs may prove useful in restoring hearing by their potential to regenerate cells in the spiral ligament.https://www.frontiersin.org/articles/10.3389/fneur.2020.580639/fullspiral ligament of the cochleacochleaimmune systemsensorineural hearing lossnoise-induced hearing loss |
| spellingShingle | Noa Peeleman Dorien Verdoodt Dorien Verdoodt Peter Ponsaerts Vincent Van Rompaey Vincent Van Rompaey On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament Frontiers in Neurology spiral ligament of the cochlea cochlea immune system sensorineural hearing loss noise-induced hearing loss |
| title | On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament |
| title_full | On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament |
| title_fullStr | On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament |
| title_full_unstemmed | On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament |
| title_short | On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament |
| title_sort | on the role of fibrocytes and the extracellular matrix in the physiology and pathophysiology of the spiral ligament |
| topic | spiral ligament of the cochlea cochlea immune system sensorineural hearing loss noise-induced hearing loss |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.580639/full |
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