Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity

Foxp3+ T-regulatory (Treg) cells are known to suppress protective host immune responses to a wide variety of solid tumors, but their therapeutic targeting is largely restricted to their transient depletion or “secondary” modulation, e.g. using anti-CTLA-4 monoclonal antibody. Our ongoing studies of...

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Bibliographic Details
Main Authors: Liqing Wang, Suresh Kumar, Satinder Dahiya, Feng Wang, Jian Wu, Kheng Newick, Rongxiang Han, Arabinda Samanta, Ulf H. Beier, Tatiana Akimova, Tricia R. Bhatti, Benjamin Nicholson, Mathew P. Kodrasov, Saket Agarwal, David E. Sterner, Wei Gu, Joseph Weinstock, Tauseef R. Butt, Steven M. Albelda, Wayne W. Hancock
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:EBioMedicine
Subjects:
Immuno-oncology
Anti-tumor immunity
T-regulatory cells
Deubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416304807

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