RET-mutated recurrent leiomyosarcoma treated with cabozantinib: a case report
We present the case of a 68-year-old man with a recurrence of a high-grade leiomyosarcoma with metastatic disease. Despite initial treatment with liposomal doxorubicin, disease progression was observed after three cycles. A molecular study revealed an activating mutation of the RET gene, and treatme...
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| Format: | Article |
| Language: | English |
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Permanyer
2023-07-01
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| Series: | Medicina Universitaria |
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| Online Access: | https://www.medicinauniversitaria.org/frame_eng.php?id=223 |
| _version_ | 1797401056670384128 |
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| author | Carlos E. Salazar-Mejía Javier A. Martínez-Moyano Hugo E. Solis-Lara Eduardo J. Cantú-Casas Frida Valle-Domínguez Valeria S. Narvaez-Gonzalez Oscar Vidal-Gutiérrez David Hernández-Barajas |
| author_facet | Carlos E. Salazar-Mejía Javier A. Martínez-Moyano Hugo E. Solis-Lara Eduardo J. Cantú-Casas Frida Valle-Domínguez Valeria S. Narvaez-Gonzalez Oscar Vidal-Gutiérrez David Hernández-Barajas |
| author_sort | Carlos E. Salazar-Mejía |
| collection | DOAJ |
| description | We present the case of a 68-year-old man with a recurrence of a high-grade leiomyosarcoma with metastatic disease. Despite initial treatment with liposomal doxorubicin, disease progression was observed after three cycles. A molecular study revealed an activating mutation of the RET gene, and treatment with cabozantinib was started at a dose of 60 mg daily. Five months later, the patient had a partial metabolic response. However, disease progression was documented two months later, and treatment was suspended. This case highlights the clinical activity of cabozantinib as monotherapy after failure of first-line chemotherapy in recurrent high-grade leiomyosarcoma with RET gene mutation.
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| first_indexed | 2024-03-09T02:04:23Z |
| format | Article |
| id | doaj.art-11bbbb42643b4f31b241d64efb9343a4 |
| institution | Directory Open Access Journal |
| issn | 1665-5796 2530-0709 |
| language | English |
| last_indexed | 2024-03-09T02:04:23Z |
| publishDate | 2023-07-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Medicina Universitaria |
| spelling | doaj.art-11bbbb42643b4f31b241d64efb9343a42023-12-07T21:05:26ZengPermanyerMedicina Universitaria1665-57962530-07092023-07-0125310.24875/RMU.23000021RET-mutated recurrent leiomyosarcoma treated with cabozantinib: a case reportCarlos E. Salazar-Mejía0Javier A. Martínez-Moyano1Hugo E. Solis-Lara2Eduardo J. Cantú-Casas3Frida Valle-Domínguez4Valeria S. Narvaez-Gonzalez5Oscar Vidal-Gutiérrez6David Hernández-Barajas7Oncology Service, Centro Universitario Contra el Cáncer, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoOncology Service, Centro Universitario Contra el Cáncer, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoDepartment of Radiology, Centro Universitario de Imagen Diagnóstica, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoDepartment of Radiology, Doctors Hospital East, Guadalupe, Nuevo León, MéxicoOncology Service, Centro Universitario Contra el Cáncer, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoOncology Service, Centro Universitario Contra el Cáncer, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoOncology Service, Centro Universitario Contra el Cáncer, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoOncology Service, Centro Universitario Contra el Cáncer, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, MexicoWe present the case of a 68-year-old man with a recurrence of a high-grade leiomyosarcoma with metastatic disease. Despite initial treatment with liposomal doxorubicin, disease progression was observed after three cycles. A molecular study revealed an activating mutation of the RET gene, and treatment with cabozantinib was started at a dose of 60 mg daily. Five months later, the patient had a partial metabolic response. However, disease progression was documented two months later, and treatment was suspended. This case highlights the clinical activity of cabozantinib as monotherapy after failure of first-line chemotherapy in recurrent high-grade leiomyosarcoma with RET gene mutation. https://www.medicinauniversitaria.org/frame_eng.php?id=223Leiomyosarcoma. Metastatic. Recurrent. RET mutation. Cabozantinib. Case report. |
| spellingShingle | Carlos E. Salazar-Mejía Javier A. Martínez-Moyano Hugo E. Solis-Lara Eduardo J. Cantú-Casas Frida Valle-Domínguez Valeria S. Narvaez-Gonzalez Oscar Vidal-Gutiérrez David Hernández-Barajas RET-mutated recurrent leiomyosarcoma treated with cabozantinib: a case report Medicina Universitaria Leiomyosarcoma. Metastatic. Recurrent. RET mutation. Cabozantinib. Case report. |
| title | RET-mutated recurrent leiomyosarcoma treated with cabozantinib: a case report |
| title_full | RET-mutated recurrent leiomyosarcoma treated with cabozantinib: a case report |
| title_fullStr | RET-mutated recurrent leiomyosarcoma treated with cabozantinib: a case report |
| title_full_unstemmed | RET-mutated recurrent leiomyosarcoma treated with cabozantinib: a case report |
| title_short | RET-mutated recurrent leiomyosarcoma treated with cabozantinib: a case report |
| title_sort | ret mutated recurrent leiomyosarcoma treated with cabozantinib a case report |
| topic | Leiomyosarcoma. Metastatic. Recurrent. RET mutation. Cabozantinib. Case report. |
| url | https://www.medicinauniversitaria.org/frame_eng.php?id=223 |
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