A case of Posterior Reversible Encephalopathy Syndrome (PRES) associated with Gilenya® (Fingolimod) treatment for Multiple Sclerosis (MS).
We describe Posterior Reversible Encephalopathy Syndrome (PRES) in a woman with Multiple Sclerosis (MS) treated with Gilenya® (Fingolimod). The first symptoms appeared after 21 months of fingolimod treatment. She experienced headache, altered mental status, cognitive deficits, seizures and visual di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-03-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00039/full |
| _version_ | 1818421587983990784 |
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| author | Hans eLindå Anders eVon Heijne |
| author_facet | Hans eLindå Anders eVon Heijne |
| author_sort | Hans eLindå |
| collection | DOAJ |
| description | We describe Posterior Reversible Encephalopathy Syndrome (PRES) in a woman with Multiple Sclerosis (MS) treated with Gilenya® (Fingolimod). The first symptoms appeared after 21 months of fingolimod treatment. She experienced headache, altered mental status, cognitive deficits, seizures and visual disturbances. Not at any time during the course of the disease could any signs of infection or rheumatic disorder be detected. Test for anti-neuronal antibodies was also negative. Her bloodpressure was normal. MRI showed widespread cortical and subcortical changes with some mass-effect in the temporo-occipital-parietal lobes in the left hemisphere. Contrast enhancement was seen in the leptomeninges and, in addition, there were no areas with restricted diffusion and no signs of hemorrhage. Her condition deteriorated until fingolimod was discontinued. Slowly her condition improved and after 8 months, the only symptoms that remained were two small, non-corresponding, right inferior scotomas. We believe that all symptoms, the clinical course and the MRI findings in this case can all be explained by considering PRES, a probably rare, but serious, side-effect of fingolimod treatment. |
| first_indexed | 2024-12-14T13:12:44Z |
| format | Article |
| id | doaj.art-11bf3ad26cfa4755a045f42d14ea5fe7 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T13:12:44Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-11bf3ad26cfa4755a045f42d14ea5fe72022-12-21T23:00:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952015-03-01610.3389/fneur.2015.00039107182A case of Posterior Reversible Encephalopathy Syndrome (PRES) associated with Gilenya® (Fingolimod) treatment for Multiple Sclerosis (MS).Hans eLindå0Anders eVon Heijne1Neurology unit, Division of Internal Medicine, Danderyd HospitalDepartment of Radiology, Danderyd HospitalWe describe Posterior Reversible Encephalopathy Syndrome (PRES) in a woman with Multiple Sclerosis (MS) treated with Gilenya® (Fingolimod). The first symptoms appeared after 21 months of fingolimod treatment. She experienced headache, altered mental status, cognitive deficits, seizures and visual disturbances. Not at any time during the course of the disease could any signs of infection or rheumatic disorder be detected. Test for anti-neuronal antibodies was also negative. Her bloodpressure was normal. MRI showed widespread cortical and subcortical changes with some mass-effect in the temporo-occipital-parietal lobes in the left hemisphere. Contrast enhancement was seen in the leptomeninges and, in addition, there were no areas with restricted diffusion and no signs of hemorrhage. Her condition deteriorated until fingolimod was discontinued. Slowly her condition improved and after 8 months, the only symptoms that remained were two small, non-corresponding, right inferior scotomas. We believe that all symptoms, the clinical course and the MRI findings in this case can all be explained by considering PRES, a probably rare, but serious, side-effect of fingolimod treatment.http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00039/fullMSfingolimodPosterior Reversible Encephalopathy SyndromeGilenyaPRES |
| spellingShingle | Hans eLindå Anders eVon Heijne A case of Posterior Reversible Encephalopathy Syndrome (PRES) associated with Gilenya® (Fingolimod) treatment for Multiple Sclerosis (MS). Frontiers in Neurology MS fingolimod Posterior Reversible Encephalopathy Syndrome Gilenya PRES |
| title | A case of Posterior Reversible Encephalopathy Syndrome (PRES) associated with Gilenya® (Fingolimod) treatment for Multiple Sclerosis (MS). |
| title_full | A case of Posterior Reversible Encephalopathy Syndrome (PRES) associated with Gilenya® (Fingolimod) treatment for Multiple Sclerosis (MS). |
| title_fullStr | A case of Posterior Reversible Encephalopathy Syndrome (PRES) associated with Gilenya® (Fingolimod) treatment for Multiple Sclerosis (MS). |
| title_full_unstemmed | A case of Posterior Reversible Encephalopathy Syndrome (PRES) associated with Gilenya® (Fingolimod) treatment for Multiple Sclerosis (MS). |
| title_short | A case of Posterior Reversible Encephalopathy Syndrome (PRES) associated with Gilenya® (Fingolimod) treatment for Multiple Sclerosis (MS). |
| title_sort | case of posterior reversible encephalopathy syndrome pres associated with gilenya 174 fingolimod treatment for multiple sclerosis ms |
| topic | MS fingolimod Posterior Reversible Encephalopathy Syndrome Gilenya PRES |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00039/full |
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