An intragenic distribution bias of DNA uptake sequences in <it>Pasteurellaceae </it>and <it>Neisseriae</it>
<p>Abstract</p> <p/> <p>Most sequenced strains from <it>Pasteurellaceae </it>and <it>Neisseriae </it>contain hundreds to thousands of uptake sequence (US) motifs in their genome, which are associated with natural competence for DNA uptake. The mechanis...
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| Format: | Article |
| Language: | English |
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BMC
2008-03-01
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| Series: | Biology Direct |
| Online Access: | http://www.biology-direct.com/content/3/1/12 |
| _version_ | 1811284953612156928 |
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| author | van Passel Mark WJ |
| author_facet | van Passel Mark WJ |
| author_sort | van Passel Mark WJ |
| collection | DOAJ |
| description | <p>Abstract</p> <p/> <p>Most sequenced strains from <it>Pasteurellaceae </it>and <it>Neisseriae </it>contain hundreds to thousands of uptake sequence (US) motifs in their genome, which are associated with natural competence for DNA uptake. The mechanism of their recognition is still unclear, and I searched for intragenic location patterns of these motifs for clues about their distribution. In all cases, one orientation of the US has a higher occurrence in the reading frame, and in all <it>Pasteurellaceae</it>, the US and the reverse complement motifs are biased towards the gene termini. These findings could help design experimental set-ups to study preferential DNA uptake, thereby further unravelling the phenomenon of natural competence.</p> <p>Reviewers</p> <p>This article was reviewed by Arcady Mushegian and I. King Jordan.</p> |
| first_indexed | 2024-04-13T02:37:19Z |
| format | Article |
| id | doaj.art-11c00a88db924bc4b58d9a6129a5ec0d |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-04-13T02:37:19Z |
| publishDate | 2008-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-11c00a88db924bc4b58d9a6129a5ec0d2022-12-22T03:06:20ZengBMCBiology Direct1745-61502008-03-01311210.1186/1745-6150-3-12An intragenic distribution bias of DNA uptake sequences in <it>Pasteurellaceae </it>and <it>Neisseriae</it>van Passel Mark WJ<p>Abstract</p> <p/> <p>Most sequenced strains from <it>Pasteurellaceae </it>and <it>Neisseriae </it>contain hundreds to thousands of uptake sequence (US) motifs in their genome, which are associated with natural competence for DNA uptake. The mechanism of their recognition is still unclear, and I searched for intragenic location patterns of these motifs for clues about their distribution. In all cases, one orientation of the US has a higher occurrence in the reading frame, and in all <it>Pasteurellaceae</it>, the US and the reverse complement motifs are biased towards the gene termini. These findings could help design experimental set-ups to study preferential DNA uptake, thereby further unravelling the phenomenon of natural competence.</p> <p>Reviewers</p> <p>This article was reviewed by Arcady Mushegian and I. King Jordan.</p>http://www.biology-direct.com/content/3/1/12 |
| spellingShingle | van Passel Mark WJ An intragenic distribution bias of DNA uptake sequences in <it>Pasteurellaceae </it>and <it>Neisseriae</it> Biology Direct |
| title | An intragenic distribution bias of DNA uptake sequences in <it>Pasteurellaceae </it>and <it>Neisseriae</it> |
| title_full | An intragenic distribution bias of DNA uptake sequences in <it>Pasteurellaceae </it>and <it>Neisseriae</it> |
| title_fullStr | An intragenic distribution bias of DNA uptake sequences in <it>Pasteurellaceae </it>and <it>Neisseriae</it> |
| title_full_unstemmed | An intragenic distribution bias of DNA uptake sequences in <it>Pasteurellaceae </it>and <it>Neisseriae</it> |
| title_short | An intragenic distribution bias of DNA uptake sequences in <it>Pasteurellaceae </it>and <it>Neisseriae</it> |
| title_sort | intragenic distribution bias of dna uptake sequences in it pasteurellaceae it and it neisseriae it |
| url | http://www.biology-direct.com/content/3/1/12 |
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