Detection of prion infectivity in fat tissues of scrapie-infected mice.
Distribution of prion infectivity in organs and tissues is important in understanding prion disease pathogenesis and designing strategies to prevent prion infection in animals and humans. Transmission of prion disease from cattle to humans resulted in banning human consumption of ruminant nervous sy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-12-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2585054?pdf=render |
| _version_ | 1819079322284064768 |
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| author | Brent Race Kimberly Meade-White Michael B A Oldstone Richard Race Bruce Chesebro |
| author_facet | Brent Race Kimberly Meade-White Michael B A Oldstone Richard Race Bruce Chesebro |
| author_sort | Brent Race |
| collection | DOAJ |
| description | Distribution of prion infectivity in organs and tissues is important in understanding prion disease pathogenesis and designing strategies to prevent prion infection in animals and humans. Transmission of prion disease from cattle to humans resulted in banning human consumption of ruminant nervous system and certain other tissues. In the present study, we surveyed tissue distribution of prion infectivity in mice with prion disease. We show for the first time detection of infectivity in white and brown fat. Since high amounts of ruminant fat are consumed by humans and also incorporated into animal feed, fat-containing tissues may pose a previously unappreciated hazard for spread of prion infection. |
| first_indexed | 2024-12-21T19:27:09Z |
| format | Article |
| id | doaj.art-11c0128f91104f52945ccfb0425014b6 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-21T19:27:09Z |
| publishDate | 2008-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-11c0128f91104f52945ccfb0425014b62022-12-21T18:52:47ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742008-12-01412e100023210.1371/journal.ppat.1000232Detection of prion infectivity in fat tissues of scrapie-infected mice.Brent RaceKimberly Meade-WhiteMichael B A OldstoneRichard RaceBruce ChesebroDistribution of prion infectivity in organs and tissues is important in understanding prion disease pathogenesis and designing strategies to prevent prion infection in animals and humans. Transmission of prion disease from cattle to humans resulted in banning human consumption of ruminant nervous system and certain other tissues. In the present study, we surveyed tissue distribution of prion infectivity in mice with prion disease. We show for the first time detection of infectivity in white and brown fat. Since high amounts of ruminant fat are consumed by humans and also incorporated into animal feed, fat-containing tissues may pose a previously unappreciated hazard for spread of prion infection.http://europepmc.org/articles/PMC2585054?pdf=render |
| spellingShingle | Brent Race Kimberly Meade-White Michael B A Oldstone Richard Race Bruce Chesebro Detection of prion infectivity in fat tissues of scrapie-infected mice. PLoS Pathogens |
| title | Detection of prion infectivity in fat tissues of scrapie-infected mice. |
| title_full | Detection of prion infectivity in fat tissues of scrapie-infected mice. |
| title_fullStr | Detection of prion infectivity in fat tissues of scrapie-infected mice. |
| title_full_unstemmed | Detection of prion infectivity in fat tissues of scrapie-infected mice. |
| title_short | Detection of prion infectivity in fat tissues of scrapie-infected mice. |
| title_sort | detection of prion infectivity in fat tissues of scrapie infected mice |
| url | http://europepmc.org/articles/PMC2585054?pdf=render |
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