A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing Patterns
A two-variable integrate and fire model is presented to study the role of transient outward potassium currents in producing temporal aspects of dorsal cochlear nucleus (DCN) pyramidal cells with different profiles namely the chopper, the pauser and the buildup. This conductance based model is a redu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2012-02-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-96&slc_lang=en&sid=1 |
| _version_ | 1797283131057766400 |
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| author | Zahra Daneshparvar Mohammad Reza Daliri |
| author_facet | Zahra Daneshparvar Mohammad Reza Daliri |
| author_sort | Zahra Daneshparvar |
| collection | DOAJ |
| description | A two-variable integrate and fire model is presented to study the role of transient outward potassium currents in producing temporal aspects of dorsal cochlear nucleus (DCN) pyramidal cells with different profiles namely the chopper, the pauser and the buildup. This conductance based model is a reduced version of KM-LIF model (Meng & Rinzel, 2010) which captures qualitative firing features of a detailed physiological model (Kanold & Manis, 2000). For our development we benefit from transient potassium currents properties i.e. fast activation and slow inactivation to generate long latency before start of firing. We compare our minimal model outputs in response to a hyperpolarizing stimulus fallowed by a depolarizing one with the data of KM-LIF model. The results conform well to the KM-LIF model with lower complexity. |
| first_indexed | 2024-03-07T17:25:51Z |
| format | Article |
| id | doaj.art-11c0d5d7c30c4aeeb095d4caef89371c |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:25:51Z |
| publishDate | 2012-02-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-11c0d5d7c30c4aeeb095d4caef89371c2024-03-02T19:07:06ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422012-02-01322231A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing PatternsZahra Daneshparvar0Mohammad Reza Daliri1 A two-variable integrate and fire model is presented to study the role of transient outward potassium currents in producing temporal aspects of dorsal cochlear nucleus (DCN) pyramidal cells with different profiles namely the chopper, the pauser and the buildup. This conductance based model is a reduced version of KM-LIF model (Meng & Rinzel, 2010) which captures qualitative firing features of a detailed physiological model (Kanold & Manis, 2000). For our development we benefit from transient potassium currents properties i.e. fast activation and slow inactivation to generate long latency before start of firing. We compare our minimal model outputs in response to a hyperpolarizing stimulus fallowed by a depolarizing one with the data of KM-LIF model. The results conform well to the KM-LIF model with lower complexity.http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-96&slc_lang=en&sid=1Neural ModelingTransient Potassium CurrentNeural FiringLatencyDorsal Cochlear Nucleus(DCN). |
| spellingShingle | Zahra Daneshparvar Mohammad Reza Daliri A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing Patterns Basic and Clinical Neuroscience Neural Modeling Transient Potassium Current Neural Firing Latency Dorsal Cochlear Nucleus(DCN). |
| title | A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing Patterns |
| title_full | A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing Patterns |
| title_fullStr | A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing Patterns |
| title_full_unstemmed | A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing Patterns |
| title_short | A Simulation-Based Study of Dorsal Cochlear Nucleus Pyramidal Cell Firing Patterns |
| title_sort | simulation based study of dorsal cochlear nucleus pyramidal cell firing patterns |
| topic | Neural Modeling Transient Potassium Current Neural Firing Latency Dorsal Cochlear Nucleus(DCN). |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-96&slc_lang=en&sid=1 |
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