Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

Acetaminophen (APAP) overdose can induce liver injury and is the most frequent cause of acute liver failure in the United States. We investigated the role of p62/SQSTM1 (referred to as p62) in APAP-induced liver injury (AILI) in mice. We found that the hepatic protein levels of p62 dramatically incr...

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Bibliographic Details
Main Authors: Hui Qian, Qingyun Bai, Xiao Yang, Jephte Y. Akakpo, Lili Ji, Li Yang, Thomas Rülicke, Kurt Zatloukal, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Autophagy
Coagulation
DILI
Liver regeneration
Macrophage
Hepatotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004421

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