M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT
The safety and effectiveness of in vitro generated M2-like macrophages for treatment of patients with ischemic and hemorrhagic brain stroke in reparative and residual periods has been evaluated. A single endolumbar administration of autologous M2-like macrophages in the mean dose of 17,9 х 106 cells...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/901 |
| _version_ | 1797237665841545216 |
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| author | S. A. Morozov G. V. Tomash E. Ya. Shevela L. V. Sakhno A. V. Smyk N. M. Starostina A. A. Ostanin E. R. Chernykh |
| author_facet | S. A. Morozov G. V. Tomash E. Ya. Shevela L. V. Sakhno A. V. Smyk N. M. Starostina A. A. Ostanin E. R. Chernykh |
| author_sort | S. A. Morozov |
| collection | DOAJ |
| description | The safety and effectiveness of in vitro generated M2-like macrophages for treatment of patients with ischemic and hemorrhagic brain stroke in reparative and residual periods has been evaluated. A single endolumbar administration of autologous M2-like macrophages in the mean dose of 17,9 х 106 cells was conducted in 13 patients with ischemic (n = 10) and hemorrhagic (n = 3) brain stroke. At 6 months after cells administration all the patients had clinical Improvement. NIHS score decreased from 8,6 ± 1,06 to 4,4 ± 0.55 (p = 0,0008), several patients showed the decrease of sensitiveness impairments, improvement of cognitive functions and enhanced quality of life. Thus, we demonstrated an ability of generation M2-like macrophages from patients with brain stroke. Endolumbar administration of these cells was safe andi didn't cause severe adverse effects and complications andi — in preliminary data — improvedi motional and cognitive functions. |
| first_indexed | 2024-03-08T12:22:47Z |
| format | Article |
| id | doaj.art-11c314710e514f39a30a3afd74131f1a |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:23:22Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-11c314710e514f39a30a3afd74131f1a2024-03-28T07:49:04ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)125128847M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENTS. A. Morozov0G. V. Tomash1E. Ya. Shevela2L. V. Sakhno3A. V. Smyk4N. M. Starostina5A. A. Ostanin6E. R. Chernykh7Research Institute of Clinical Immunology SD RAMSResearch Institute of Clinical Immunology SD RAMSResearch Institute of Clinical Immunology SD RAMSResearch Institute of Clinical Immunology SD RAMSResearch Institute of Clinical Immunology SD RAMSResearch Institute of Clinical Immunology SD RAMSResearch Institute of Clinical Immunology SD RAMSResearch Institute of Clinical Immunology SD RAMSThe safety and effectiveness of in vitro generated M2-like macrophages for treatment of patients with ischemic and hemorrhagic brain stroke in reparative and residual periods has been evaluated. A single endolumbar administration of autologous M2-like macrophages in the mean dose of 17,9 х 106 cells was conducted in 13 patients with ischemic (n = 10) and hemorrhagic (n = 3) brain stroke. At 6 months after cells administration all the patients had clinical Improvement. NIHS score decreased from 8,6 ± 1,06 to 4,4 ± 0.55 (p = 0,0008), several patients showed the decrease of sensitiveness impairments, improvement of cognitive functions and enhanced quality of life. Thus, we demonstrated an ability of generation M2-like macrophages from patients with brain stroke. Endolumbar administration of these cells was safe andi didn't cause severe adverse effects and complications andi — in preliminary data — improvedi motional and cognitive functions.https://www.actabiomedica.ru/jour/article/view/901brain strokem2-like macrophages |
| spellingShingle | S. A. Morozov G. V. Tomash E. Ya. Shevela L. V. Sakhno A. V. Smyk N. M. Starostina A. A. Ostanin E. R. Chernykh M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT Acta Biomedica Scientifica brain stroke m2-like macrophages |
| title | M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT |
| title_full | M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT |
| title_fullStr | M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT |
| title_full_unstemmed | M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT |
| title_short | M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT |
| title_sort | m2 like macrophages are potential candidates for brain stroke outcomes treatment |
| topic | brain stroke m2-like macrophages |
| url | https://www.actabiomedica.ru/jour/article/view/901 |
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