Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs
The late-stage C–H functionalization of bioactive structural motifs is a powerful synthetic strategy for accessing advanced agrochemicals, bioimaging materials, and drug candidates, among other complex molecules. While traditional late-stage diversification relies on the use of precious transition m...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2021-07-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.17.122 |
| _version_ | 1818649291500027904 |
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| author | Jongwoo Son |
| author_facet | Jongwoo Son |
| author_sort | Jongwoo Son |
| collection | DOAJ |
| description | The late-stage C–H functionalization of bioactive structural motifs is a powerful synthetic strategy for accessing advanced agrochemicals, bioimaging materials, and drug candidates, among other complex molecules. While traditional late-stage diversification relies on the use of precious transition metals, the utilization of 3d transition metals is an emerging approach in organic synthesis. Among the 3d metals, manganese catalysts have gained increasing attention for late-stage diversification due to the sustainability, cost-effectiveness, ease of operation, and reduced toxicity. Herein, we summarize recent manganese-catalyzed late-stage C–H functionalization reactions of biologically active small molecules and complex peptides. |
| first_indexed | 2024-12-17T01:31:59Z |
| format | Article |
| id | doaj.art-11c49bc376f246f98fbd7faca4671f2c |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-17T01:31:59Z |
| publishDate | 2021-07-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-11c49bc376f246f98fbd7faca4671f2c2022-12-21T22:08:32ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972021-07-011711733175110.3762/bjoc.17.1221860-5397-17-122Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifsJongwoo Son0Department of Chemistry, Dong-A University, Busan 49315, South KoreaThe late-stage C–H functionalization of bioactive structural motifs is a powerful synthetic strategy for accessing advanced agrochemicals, bioimaging materials, and drug candidates, among other complex molecules. While traditional late-stage diversification relies on the use of precious transition metals, the utilization of 3d transition metals is an emerging approach in organic synthesis. Among the 3d metals, manganese catalysts have gained increasing attention for late-stage diversification due to the sustainability, cost-effectiveness, ease of operation, and reduced toxicity. Herein, we summarize recent manganese-catalyzed late-stage C–H functionalization reactions of biologically active small molecules and complex peptides.https://doi.org/10.3762/bjoc.17.122bioactive molecules3d transition metalslate-stage functionalizationmanganese catalystsustainable catalysis |
| spellingShingle | Jongwoo Son Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs Beilstein Journal of Organic Chemistry bioactive molecules 3d transition metals late-stage functionalization manganese catalyst sustainable catalysis |
| title | Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs |
| title_full | Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs |
| title_fullStr | Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs |
| title_full_unstemmed | Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs |
| title_short | Sustainable manganese catalysis for late-stage C–H functionalization of bioactive structural motifs |
| title_sort | sustainable manganese catalysis for late stage c h functionalization of bioactive structural motifs |
| topic | bioactive molecules 3d transition metals late-stage functionalization manganese catalyst sustainable catalysis |
| url | https://doi.org/10.3762/bjoc.17.122 |
| work_keys_str_mv | AT jongwooson sustainablemanganesecatalysisforlatestagechfunctionalizationofbioactivestructuralmotifs |