The Effect of Solifenacin on Cognitive Function following Stroke
Background/Aims: Our aim was to investigate the effect of solifenacin (an anticholinergic) on cognitive function after stroke. Methods: We retrospectively reviewed 66 stroke cases who were prescribed solifenacin for more than 2 months. A control group was generated matching the patients both for sex...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2013-05-01
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| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/350029 |
| _version_ | 1818852708915871744 |
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| author | Jin-Woo Park |
| author_facet | Jin-Woo Park |
| author_sort | Jin-Woo Park |
| collection | DOAJ |
| description | Background/Aims: Our aim was to investigate the effect of solifenacin (an anticholinergic) on cognitive function after stroke. Methods: We retrospectively reviewed 66 stroke cases who were prescribed solifenacin for more than 2 months. A control group was generated matching the patients both for sex and age. The interval changes in the Mini-Mental State Examination (MMSE) score and Clinical Dementia Rating Sum of Boxes (CDR-SB) score after solifenacin administration were compared to those of the control group. Results: The baseline MMSE score of the control group was 15.9 ± 9.2 and that of the solifenacin group was 14.3 ± 7.8. After using solifenacin for an average of 76.9 days, there was a change in the MMSE score of 1.9 ± 5.2. During similar periods, there was a change in the MMSE score of 2.9 ± 3.7 in the control group (not using solifenacin). However, there was no significant difference between the two groups. Similarly, there was no significant difference in the CDR-SB score between the two groups. Conclusion: Solifenacin treatment did not affect the short-term cognitive performance in stroke patients. This information might be useful when prescribing anticholinergics to stroke patients. |
| first_indexed | 2024-12-19T07:25:13Z |
| format | Article |
| id | doaj.art-11c4bbf8f9d34025a7da1108028e0476 |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-12-19T07:25:13Z |
| publishDate | 2013-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-11c4bbf8f9d34025a7da1108028e04762022-12-21T20:30:51ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642013-05-013114314710.1159/000350029350029The Effect of Solifenacin on Cognitive Function following StrokeJin-Woo ParkBackground/Aims: Our aim was to investigate the effect of solifenacin (an anticholinergic) on cognitive function after stroke. Methods: We retrospectively reviewed 66 stroke cases who were prescribed solifenacin for more than 2 months. A control group was generated matching the patients both for sex and age. The interval changes in the Mini-Mental State Examination (MMSE) score and Clinical Dementia Rating Sum of Boxes (CDR-SB) score after solifenacin administration were compared to those of the control group. Results: The baseline MMSE score of the control group was 15.9 ± 9.2 and that of the solifenacin group was 14.3 ± 7.8. After using solifenacin for an average of 76.9 days, there was a change in the MMSE score of 1.9 ± 5.2. During similar periods, there was a change in the MMSE score of 2.9 ± 3.7 in the control group (not using solifenacin). However, there was no significant difference between the two groups. Similarly, there was no significant difference in the CDR-SB score between the two groups. Conclusion: Solifenacin treatment did not affect the short-term cognitive performance in stroke patients. This information might be useful when prescribing anticholinergics to stroke patients.http://www.karger.com/Article/FullText/350029AnticholinergicsSolifenacinStrokeCognitive symptomsMuscarinic receptors |
| spellingShingle | Jin-Woo Park The Effect of Solifenacin on Cognitive Function following Stroke Dementia and Geriatric Cognitive Disorders Extra Anticholinergics Solifenacin Stroke Cognitive symptoms Muscarinic receptors |
| title | The Effect of Solifenacin on Cognitive Function following Stroke |
| title_full | The Effect of Solifenacin on Cognitive Function following Stroke |
| title_fullStr | The Effect of Solifenacin on Cognitive Function following Stroke |
| title_full_unstemmed | The Effect of Solifenacin on Cognitive Function following Stroke |
| title_short | The Effect of Solifenacin on Cognitive Function following Stroke |
| title_sort | effect of solifenacin on cognitive function following stroke |
| topic | Anticholinergics Solifenacin Stroke Cognitive symptoms Muscarinic receptors |
| url | http://www.karger.com/Article/FullText/350029 |
| work_keys_str_mv | AT jinwoopark theeffectofsolifenacinoncognitivefunctionfollowingstroke AT jinwoopark effectofsolifenacinoncognitivefunctionfollowingstroke |