Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition

Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition

Summary: IL-17-producing helper T (Th17) cells are long-lived and serve as central effector cells in chronic autoimmune diseases. The underlying mechanisms of Th17 persistence remain unclear. We demonstrated that abatacept, a CD28 antagonist, effectively prevented the development of skin disease in...

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Bibliographic Details
Main Authors: By Yukiko Tokifuji, Hodaka Hayabuchi, Takashi Sasaki, Mariko Hara-Chikuma, Keiji Hirota, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura, Shunsuke Chikuma
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Molecular biology
Immunity
Cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223027232

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