Hospital-acquired infections due to carbapenem-resistant Providencia stuartii
Background & objectives: During the course of a retrospective survey on healthcare associated infections (HAIs) due to carbapenem-resistant organisms, an unusual prevalence of HAIs due to carbapenem-resistant Providencia stuartii (CRPS) was found. Hence this study aimed to conduct the occurrence...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Medical Research |
| Subjects: | |
| Online Access: | http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2023;volume=158;issue=2;spage=145;epage=150;aulast=Sharma |
| _version_ | 1797649340238397440 |
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| author | Swati Sharma Sangita Pramanik Pooja Marndi Tuhina Banerjee |
| author_facet | Swati Sharma Sangita Pramanik Pooja Marndi Tuhina Banerjee |
| author_sort | Swati Sharma |
| collection | DOAJ |
| description | Background & objectives: During the course of a retrospective survey on healthcare associated infections (HAIs) due to carbapenem-resistant organisms, an unusual prevalence of HAIs due to carbapenem-resistant Providencia stuartii (CRPS) was found. Hence this study aimed to conduct the occurrence of P. stuartii associated HAIs with special reference to the drug resistance profiling of these isolates.
Methods: Of the eight total HAI cases (7.5% of total HAIs and 33.3% of HAIs due to Enterobacterales) of CRPS infections included in this study, three were reported from ventilator-associated pneumonia (VAP), three were surgical site infections (SSIs), one was a catheter-associated urinary tract infection (CAUTI) and one was a bloodstream infection. All the eight CRPS isolates were tested for extended-spectrum β-lactamases production, AmpC hyperproduction as well as carbapenem resistance. Typing of the isolates was performed by repetitive extragenic palindromic polymerase chain reaction (REP-PCR).
Results: All the eight isolates of CRPS were found to be AmpC hyperproducers, carbapenemase producers, and harboured chromosomally located blaNDM in seven isolates and blaIMP genes in one. All the cases with CRPS infections had prior history of colistin therapy along with prolonged hospital stay (>20 days). The cases were located in five different wards/intensive care unit (ICU) within the hospital in one year. However, strain typing by REP-PCR revealed 100 per cent similarity and clonal relatedness in all the seven isolates carrying blaNDM genes. Interestingly, routine hospital surveillance revealed a high carriage of P. stuartii in the axilla of patients admitted to the ICU.
Interpretation & conclusions: The study findings suggest CRPS as an important cause of HAIs. This organism often goes unnoticed due to the burden of carbapenem resistance in other Enterobacterales and non-fermenters. |
| first_indexed | 2024-03-11T15:44:45Z |
| format | Article |
| id | doaj.art-11c4fc5fbade46d1b96eca39ab590249 |
| institution | Directory Open Access Journal |
| issn | 0971-5916 |
| language | English |
| last_indexed | 2024-03-11T15:44:45Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Research |
| spelling | doaj.art-11c4fc5fbade46d1b96eca39ab5902492023-10-26T06:41:30ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Research0971-59162023-01-01158214515010.4103/ijmr.IJMR_3668_20Hospital-acquired infections due to carbapenem-resistant Providencia stuartiiSwati SharmaSangita PramanikPooja MarndiTuhina BanerjeeBackground & objectives: During the course of a retrospective survey on healthcare associated infections (HAIs) due to carbapenem-resistant organisms, an unusual prevalence of HAIs due to carbapenem-resistant Providencia stuartii (CRPS) was found. Hence this study aimed to conduct the occurrence of P. stuartii associated HAIs with special reference to the drug resistance profiling of these isolates. Methods: Of the eight total HAI cases (7.5% of total HAIs and 33.3% of HAIs due to Enterobacterales) of CRPS infections included in this study, three were reported from ventilator-associated pneumonia (VAP), three were surgical site infections (SSIs), one was a catheter-associated urinary tract infection (CAUTI) and one was a bloodstream infection. All the eight CRPS isolates were tested for extended-spectrum β-lactamases production, AmpC hyperproduction as well as carbapenem resistance. Typing of the isolates was performed by repetitive extragenic palindromic polymerase chain reaction (REP-PCR). Results: All the eight isolates of CRPS were found to be AmpC hyperproducers, carbapenemase producers, and harboured chromosomally located blaNDM in seven isolates and blaIMP genes in one. All the cases with CRPS infections had prior history of colistin therapy along with prolonged hospital stay (>20 days). The cases were located in five different wards/intensive care unit (ICU) within the hospital in one year. However, strain typing by REP-PCR revealed 100 per cent similarity and clonal relatedness in all the seven isolates carrying blaNDM genes. Interestingly, routine hospital surveillance revealed a high carriage of P. stuartii in the axilla of patients admitted to the ICU. Interpretation & conclusions: The study findings suggest CRPS as an important cause of HAIs. This organism often goes unnoticed due to the burden of carbapenem resistance in other Enterobacterales and non-fermenters.http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2023;volume=158;issue=2;spage=145;epage=150;aulast=Sharmaampc - blandm - carbapenem-resistant p. stuartii - colistin - intensive care unit |
| spellingShingle | Swati Sharma Sangita Pramanik Pooja Marndi Tuhina Banerjee Hospital-acquired infections due to carbapenem-resistant Providencia stuartii Indian Journal of Medical Research ampc - blandm - carbapenem-resistant p. stuartii - colistin - intensive care unit |
| title | Hospital-acquired infections due to carbapenem-resistant Providencia stuartii |
| title_full | Hospital-acquired infections due to carbapenem-resistant Providencia stuartii |
| title_fullStr | Hospital-acquired infections due to carbapenem-resistant Providencia stuartii |
| title_full_unstemmed | Hospital-acquired infections due to carbapenem-resistant Providencia stuartii |
| title_short | Hospital-acquired infections due to carbapenem-resistant Providencia stuartii |
| title_sort | hospital acquired infections due to carbapenem resistant providencia stuartii |
| topic | ampc - blandm - carbapenem-resistant p. stuartii - colistin - intensive care unit |
| url | http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2023;volume=158;issue=2;spage=145;epage=150;aulast=Sharma |
| work_keys_str_mv | AT swatisharma hospitalacquiredinfectionsduetocarbapenemresistantprovidenciastuartii AT sangitapramanik hospitalacquiredinfectionsduetocarbapenemresistantprovidenciastuartii AT poojamarndi hospitalacquiredinfectionsduetocarbapenemresistantprovidenciastuartii AT tuhinabanerjee hospitalacquiredinfectionsduetocarbapenemresistantprovidenciastuartii |