Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fraction
Objective: The aim of the present study was to find a correlation of serum Suppression of tumorigenicity 2 (ST2) levels with severity of diastolic dysfunction on echocardiography and cardiac magnetic resonance imaging (CMRI) in heart failure with preserved ejection fraction (HFpEF) patients. Methods...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-05-01
|
| Series: | Indian Heart Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483222000347 |
| _version_ | 1811241099946098688 |
|---|---|
| author | Vivek Agrawal Suhas Hardas Hasmukh Gujar Deepak S. Phalgune |
| author_facet | Vivek Agrawal Suhas Hardas Hasmukh Gujar Deepak S. Phalgune |
| author_sort | Vivek Agrawal |
| collection | DOAJ |
| description | Objective: The aim of the present study was to find a correlation of serum Suppression of tumorigenicity 2 (ST2) levels with severity of diastolic dysfunction on echocardiography and cardiac magnetic resonance imaging (CMRI) in heart failure with preserved ejection fraction (HFpEF) patients. Methods: Fifty patients aged ≥18 years fulfilling diagnostic criteria for HFpEF were included. ST2 levels, 2D echocardiography and CMRI were performed. Left ventricular ejection fraction, E/A, Septal E/E’, left atrial volume index (LAVI), tricuspid regurgitation (TR), assessment of diastolic dysfunction, T1 mapping in milliseconds and late gadolinium enhancement (LGE) in percentage were noted. The primary outcome measure was to study correlation of ST2 levels with severity of diastolic dysfunction, whereas the secondary outcome measures were to study correlation of ST2 levels with native T1 mapping and LGE on CMRI. Results: ST2 levels showed statistically significant and positive correlation with E/E’ (r = 0.837), peak TR velocity (r = 0.373), LAVI (r = 0.74), E/A (r = 0.420), and T1 values in milliseconds (r = 0.619). There was no statistically significant correlation between ST2 level and LGE in % (r = 0.145). The median ST2 levels in patients with E/E’ > 14 and E/E’ ≤ 14 were 110.8 and 36.1 respectively (p-value < 0.05). The mean ST2 levels were significantly higher in patients who had diastolic dysfunction grade III (126.4) and New York Heart Association class IV (133.3). Conclusions: Evaluation of ST2 adds important information to support the diagnosis of left ventricular diastolic dysfunction in patients with HFpEF. |
| first_indexed | 2024-04-12T13:30:44Z |
| format | Article |
| id | doaj.art-11c8c8af94004b4c9ce9eef431525895 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-04-12T13:30:44Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-11c8c8af94004b4c9ce9eef4315258952022-12-22T03:31:11ZengElsevierIndian Heart Journal0019-48322022-05-01743229234Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fractionVivek Agrawal0Suhas Hardas1Hasmukh Gujar2Deepak S. Phalgune3Dept. of Cardiology, Poona Hospital & Research Centre, Pune, IndiaDept. of Cardiology, Poona Hospital & Research Centre, Pune, IndiaDept. of Cardiology, Poona Hospital & Research Centre, Pune, IndiaDept. of Research, Poona Hospital & Research Centre, Pune, India; Corresponding author. Poona Hospital and Research Centre, Sadashiv Peth, Pune, 411030, India.Objective: The aim of the present study was to find a correlation of serum Suppression of tumorigenicity 2 (ST2) levels with severity of diastolic dysfunction on echocardiography and cardiac magnetic resonance imaging (CMRI) in heart failure with preserved ejection fraction (HFpEF) patients. Methods: Fifty patients aged ≥18 years fulfilling diagnostic criteria for HFpEF were included. ST2 levels, 2D echocardiography and CMRI were performed. Left ventricular ejection fraction, E/A, Septal E/E’, left atrial volume index (LAVI), tricuspid regurgitation (TR), assessment of diastolic dysfunction, T1 mapping in milliseconds and late gadolinium enhancement (LGE) in percentage were noted. The primary outcome measure was to study correlation of ST2 levels with severity of diastolic dysfunction, whereas the secondary outcome measures were to study correlation of ST2 levels with native T1 mapping and LGE on CMRI. Results: ST2 levels showed statistically significant and positive correlation with E/E’ (r = 0.837), peak TR velocity (r = 0.373), LAVI (r = 0.74), E/A (r = 0.420), and T1 values in milliseconds (r = 0.619). There was no statistically significant correlation between ST2 level and LGE in % (r = 0.145). The median ST2 levels in patients with E/E’ > 14 and E/E’ ≤ 14 were 110.8 and 36.1 respectively (p-value < 0.05). The mean ST2 levels were significantly higher in patients who had diastolic dysfunction grade III (126.4) and New York Heart Association class IV (133.3). Conclusions: Evaluation of ST2 adds important information to support the diagnosis of left ventricular diastolic dysfunction in patients with HFpEF.http://www.sciencedirect.com/science/article/pii/S0019483222000347Heart failure with a preserved ejection fraction (HFpEF)Cardiac magnetic resonance imaging (CMRI)Suppression of tumorigenicity 2 (ST2)CorrelationLate gadolinium enhancement (LGE) |
| spellingShingle | Vivek Agrawal Suhas Hardas Hasmukh Gujar Deepak S. Phalgune Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fraction Indian Heart Journal Heart failure with a preserved ejection fraction (HFpEF) Cardiac magnetic resonance imaging (CMRI) Suppression of tumorigenicity 2 (ST2) Correlation Late gadolinium enhancement (LGE) |
| title | Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fraction |
| title_full | Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fraction |
| title_fullStr | Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fraction |
| title_full_unstemmed | Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fraction |
| title_short | Correlation of serum ST2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac MRI in patients with heart failure with preserved ejection fraction |
| title_sort | correlation of serum st2 levels with severity of diastolic dysfunction on echocardiography and findings on cardiac mri in patients with heart failure with preserved ejection fraction |
| topic | Heart failure with a preserved ejection fraction (HFpEF) Cardiac magnetic resonance imaging (CMRI) Suppression of tumorigenicity 2 (ST2) Correlation Late gadolinium enhancement (LGE) |
| url | http://www.sciencedirect.com/science/article/pii/S0019483222000347 |
| work_keys_str_mv | AT vivekagrawal correlationofserumst2levelswithseverityofdiastolicdysfunctiononechocardiographyandfindingsoncardiacmriinpatientswithheartfailurewithpreservedejectionfraction AT suhashardas correlationofserumst2levelswithseverityofdiastolicdysfunctiononechocardiographyandfindingsoncardiacmriinpatientswithheartfailurewithpreservedejectionfraction AT hasmukhgujar correlationofserumst2levelswithseverityofdiastolicdysfunctiononechocardiographyandfindingsoncardiacmriinpatientswithheartfailurewithpreservedejectionfraction AT deepaksphalgune correlationofserumst2levelswithseverityofdiastolicdysfunctiononechocardiographyandfindingsoncardiacmriinpatientswithheartfailurewithpreservedejectionfraction |