Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis
Abstract Background Although Respiratory syncytial virus (RSV) is one of the common pathogens in children with pertussis and viral coinfection, the clinical impact of RSV infection on pertussis remains unclear. We compared clinical characteristics and sought differences between infants with single B...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-021-05863-9 |
| _version_ | 1818408691368460288 |
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| author | Ruimu Zhang Jikui Deng |
| author_facet | Ruimu Zhang Jikui Deng |
| author_sort | Ruimu Zhang |
| collection | DOAJ |
| description | Abstract Background Although Respiratory syncytial virus (RSV) is one of the common pathogens in children with pertussis and viral coinfection, the clinical impact of RSV infection on pertussis remains unclear. We compared clinical characteristics and sought differences between infants with single Bordetella pertussis (B. pertussis) infection and those with RSV coinfection. Methods We enrolled 80 patients with pertussis who were hospitalized in Shenzhen Children’s Hospital from January 2017 to December 2019. Respiratory tract samples were tested for B. pertussis with real-time polymerase chain reaction and respiratory viruses with immunofluorescence assay. Clinical data were obtained from hospital records and collected using a structured questionnaire. Results Thirty-seven of 80 patients had B. pertussis infection alone (pertussis group) and 43 had RSV-pertussis coinfection (coinfection group). No significant differences were found with regard to sex, body weight, preterm birth history, pertussis vaccination, symptoms, presence of pneumonia, or lymphocyte count between the 2 groups. Univariate analysis showed patients with RSV coinfection were older (median, 4.57 months vs 4.03 months, p = 0.048); more commonly treated with β-lactam antibiotics (21% vs 5%, p = 0.044); had higher rates of wheezes (40% vs 14%, p = 0.009) and rales (35% vs 14%, p = 0.028) on chest auscultation, a higher rate of readmission (40% vs 11%, p = 0.004), and a longer hospital stay (median, 10 days vs 7 days, p = 0.002). In the further binary logistic regression analysis, patients with RSV coinfection had higher rates of wheezes (OR = 3.802; 95% CI: 1.106 to 13.072; p = 0.034) and readmission (OR = 5.835; 95% CI: 1.280 to 26.610; p = 0.023). Conclusions RSV coinfection increases readmission rate in children hospitalized for pertussis. RSV infection should be suspected when wheezes are present on auscultation of the chest in these patients. Early detection of RSV may avoid unnecessary antibiotic use. |
| first_indexed | 2024-12-14T09:47:45Z |
| format | Article |
| id | doaj.art-11c921e6bce0417bb9ee414cbc4e883f |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T09:47:45Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-11c921e6bce0417bb9ee414cbc4e883f2022-12-21T23:07:36ZengBMCBMC Infectious Diseases1471-23342021-02-012111510.1186/s12879-021-05863-9Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussisRuimu Zhang0Jikui Deng1Department of Infectious Diseases, Shenzhen Children’s HospitalDepartment of Infectious Diseases, Shenzhen Children’s HospitalAbstract Background Although Respiratory syncytial virus (RSV) is one of the common pathogens in children with pertussis and viral coinfection, the clinical impact of RSV infection on pertussis remains unclear. We compared clinical characteristics and sought differences between infants with single Bordetella pertussis (B. pertussis) infection and those with RSV coinfection. Methods We enrolled 80 patients with pertussis who were hospitalized in Shenzhen Children’s Hospital from January 2017 to December 2019. Respiratory tract samples were tested for B. pertussis with real-time polymerase chain reaction and respiratory viruses with immunofluorescence assay. Clinical data were obtained from hospital records and collected using a structured questionnaire. Results Thirty-seven of 80 patients had B. pertussis infection alone (pertussis group) and 43 had RSV-pertussis coinfection (coinfection group). No significant differences were found with regard to sex, body weight, preterm birth history, pertussis vaccination, symptoms, presence of pneumonia, or lymphocyte count between the 2 groups. Univariate analysis showed patients with RSV coinfection were older (median, 4.57 months vs 4.03 months, p = 0.048); more commonly treated with β-lactam antibiotics (21% vs 5%, p = 0.044); had higher rates of wheezes (40% vs 14%, p = 0.009) and rales (35% vs 14%, p = 0.028) on chest auscultation, a higher rate of readmission (40% vs 11%, p = 0.004), and a longer hospital stay (median, 10 days vs 7 days, p = 0.002). In the further binary logistic regression analysis, patients with RSV coinfection had higher rates of wheezes (OR = 3.802; 95% CI: 1.106 to 13.072; p = 0.034) and readmission (OR = 5.835; 95% CI: 1.280 to 26.610; p = 0.023). Conclusions RSV coinfection increases readmission rate in children hospitalized for pertussis. RSV infection should be suspected when wheezes are present on auscultation of the chest in these patients. Early detection of RSV may avoid unnecessary antibiotic use.https://doi.org/10.1186/s12879-021-05863-9PertussisRespiratory syncytial virusChildren |
| spellingShingle | Ruimu Zhang Jikui Deng Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis BMC Infectious Diseases Pertussis Respiratory syncytial virus Children |
| title | Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis |
| title_full | Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis |
| title_fullStr | Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis |
| title_full_unstemmed | Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis |
| title_short | Clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis |
| title_sort | clinical impact of respiratory syncytial virus infection on children hospitalized for pertussis |
| topic | Pertussis Respiratory syncytial virus Children |
| url | https://doi.org/10.1186/s12879-021-05863-9 |
| work_keys_str_mv | AT ruimuzhang clinicalimpactofrespiratorysyncytialvirusinfectiononchildrenhospitalizedforpertussis AT jikuideng clinicalimpactofrespiratorysyncytialvirusinfectiononchildrenhospitalizedforpertussis |