Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling

Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling

Disruption of androgen signaling is known to cause testicular malformation and defective spermatogenesis in zebrafish. However, knockout of cyp17a1, a key enzyme responsible for the androgen synthesis, in ar-/- male zebrafish paradoxically causes testicular hypertrophy and enhanced spermatogenesis....

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Bibliographic Details
Main Authors: Gang Zhai, Tingting Shu, Guangqing Yu, Haipei Tang, Chuang Shi, Jingyi Jia, Qiyong Lou, Xiangyan Dai, Xia Jin, Jiangyan He, Wuhan Xiao, Xiaochun Liu, Zhan Yin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
testis organization
spermatogenesis
androgen signaling
Online Access:https://elifesciences.org/articles/66118

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