Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical Studies
The sentinel lymph node is the first lymph node from the primary tumor. Sentinel lymph node biopsy (SLNB) is a surgical procedure that can detect occult nodal metastasis with relatively low morbidity. It may also have a therapeutic effect via regional disease control. The Multicenter Selective Lymph...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/13/3291 |
| _version_ | 1797592036769005568 |
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| author | Shoichiro Ishizuki Yoshiyuki Nakamura |
| author_facet | Shoichiro Ishizuki Yoshiyuki Nakamura |
| author_sort | Shoichiro Ishizuki |
| collection | DOAJ |
| description | The sentinel lymph node is the first lymph node from the primary tumor. Sentinel lymph node biopsy (SLNB) is a surgical procedure that can detect occult nodal metastasis with relatively low morbidity. It may also have a therapeutic effect via regional disease control. The Multicenter Selective Lymphadenectomy-I (MSLT-I) trial revealed a prognostic benefit from SLNB in melanoma patients. However, it remains unclear whether there is a prognostic benefit from SLNB in patients with nonmelanoma skin cancer owing to a lack of randomized prospective studies. Nevertheless, SLNB provides important information about nodal status, which is one of the strongest factors to predict prognosis and may guide additional nodal treatment. Currently, SLNB is widely used in the management of not only patients with melanoma but also those with nonmelanoma skin cancer. However, the utilization and outcomes of SLNB differ among skin cancers. In addition, SLNB is not recommended for routine use in all patients with skin cancer. In this review, we provide a summary of the role of SLNB and of the indications for SLNB in each skin cancer based on previously published articles. |
| first_indexed | 2024-03-11T01:45:47Z |
| format | Article |
| id | doaj.art-11cbc58032fe407494e1107843d1a747 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:45:47Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-11cbc58032fe407494e1107843d1a7472023-11-18T16:14:50ZengMDPI AGCancers2072-66942023-06-011513329110.3390/cancers15133291Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical StudiesShoichiro Ishizuki0Yoshiyuki Nakamura1Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, JapanDepartment of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, JapanThe sentinel lymph node is the first lymph node from the primary tumor. Sentinel lymph node biopsy (SLNB) is a surgical procedure that can detect occult nodal metastasis with relatively low morbidity. It may also have a therapeutic effect via regional disease control. The Multicenter Selective Lymphadenectomy-I (MSLT-I) trial revealed a prognostic benefit from SLNB in melanoma patients. However, it remains unclear whether there is a prognostic benefit from SLNB in patients with nonmelanoma skin cancer owing to a lack of randomized prospective studies. Nevertheless, SLNB provides important information about nodal status, which is one of the strongest factors to predict prognosis and may guide additional nodal treatment. Currently, SLNB is widely used in the management of not only patients with melanoma but also those with nonmelanoma skin cancer. However, the utilization and outcomes of SLNB differ among skin cancers. In addition, SLNB is not recommended for routine use in all patients with skin cancer. In this review, we provide a summary of the role of SLNB and of the indications for SLNB in each skin cancer based on previously published articles.https://www.mdpi.com/2072-6694/15/13/3291skin cancersurgical marginlymph node dissectionskin graft |
| spellingShingle | Shoichiro Ishizuki Yoshiyuki Nakamura Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical Studies Cancers skin cancer surgical margin lymph node dissection skin graft |
| title | Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical Studies |
| title_full | Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical Studies |
| title_fullStr | Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical Studies |
| title_full_unstemmed | Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical Studies |
| title_short | Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical Studies |
| title_sort | role of sentinel lymph node biopsy for skin cancer based on clinical studies |
| topic | skin cancer surgical margin lymph node dissection skin graft |
| url | https://www.mdpi.com/2072-6694/15/13/3291 |
| work_keys_str_mv | AT shoichiroishizuki roleofsentinellymphnodebiopsyforskincancerbasedonclinicalstudies AT yoshiyukinakamura roleofsentinellymphnodebiopsyforskincancerbasedonclinicalstudies |