The Effect of COVID-19 Infection on Severity of Acute Pancreatitis: A Prospective Cohort Study
Background: Coronavirus Disease 2019 (COVID-19) is multisystemic disorder. It uses angiotensin converting enzyme 2 (ACE2) to gain access to human cells. The ACE2 receptor is present on cell types, one of them is pancreatic cell. This study aimed to assess the impact of COVID 19 infection on sever...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2024-04-01
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| Series: | مجله كليه طب الكندي |
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| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1131 |
| _version_ | 1797224447837470720 |
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| author | Kamal Al-Jawdah Furat Abdulhussein Aboodi Qasem Abdulzahra Al Behadili Muthana Haroon |
| author_facet | Kamal Al-Jawdah Furat Abdulhussein Aboodi Qasem Abdulzahra Al Behadili Muthana Haroon |
| author_sort | Kamal Al-Jawdah |
| collection | DOAJ |
| description |
Background: Coronavirus Disease 2019 (COVID-19) is multisystemic disorder. It uses angiotensin converting enzyme 2 (ACE2) to gain access to human cells. The ACE2 receptor is present on cell types, one of them is pancreatic cell.
This study aimed to assess the impact of COVID 19 infection on severity of acute pancreatitis (AP).
Subjects and Methods: A prospective cohort study that was conducted at a major teaching hospital. The study group included all cases of AP with COVID 19. Medical records of randomly selected fifty cases of AP presented one year before COVID 19 pandemic with matching months of the year were considered as control. A comparison of the effect of COVID 19 on the severity of AP was done by measuring Glasgow and revised Atlanta scores.
Results: 37 cases of COVID 19 patients developed AP in this study. The serum calcium, and albumin were lower, while blood urea, sugar, and Glasgow score all were higher in cases of COVID 19 than control. Follow up, showed that 17 (19.5%) of the cases developed severe pancreatitis, 76.5% of severe cases of AP had COVID 19 on comparison to control. COVID 19 is an independent predictor for severity of AP.
Conclusions: COVID 19 is an independent predictor for severity of AP. More directed care to the cases of COVID 19 with superimposed AP, as they prone to develop severe form. Future studies to examine the effect of COVID 19 antiviral therapy on the severity of AP is recommended.
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| first_indexed | 2024-04-24T13:53:16Z |
| format | Article |
| id | doaj.art-11cbc64bb9e74287b6d08ff45f739712 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-04-24T13:53:16Z |
| publishDate | 2024-04-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-11cbc64bb9e74287b6d08ff45f7397122024-04-03T22:59:13ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652024-04-0120110.47723/6pc8v3781057The Effect of COVID-19 Infection on Severity of Acute Pancreatitis: A Prospective Cohort StudyKamal Al-Jawdah0https://orcid.org/0000-0003-0776-468XFurat Abdulhussein Aboodi1https://orcid.org/0009-0000-0574-6985Qasem Abdulzahra Al Behadili2https://orcid.org/0009-0003-8004-6892Muthana Haroon3https://orcid.org/0000-0001-8575-1732Al-Kindy College of Medicine, University of Baghdad, Baghdad, IraqAl-Kindy Teaching Hospital, Alrisafa Health directorate, Baghdad, Iraq Al-Shaheed Al-Sadr General Hospital, Alrisafa Health directorate, Baghdad, Iraq HSE, Naas General Hospital, Naas, Ireland Background: Coronavirus Disease 2019 (COVID-19) is multisystemic disorder. It uses angiotensin converting enzyme 2 (ACE2) to gain access to human cells. The ACE2 receptor is present on cell types, one of them is pancreatic cell. This study aimed to assess the impact of COVID 19 infection on severity of acute pancreatitis (AP). Subjects and Methods: A prospective cohort study that was conducted at a major teaching hospital. The study group included all cases of AP with COVID 19. Medical records of randomly selected fifty cases of AP presented one year before COVID 19 pandemic with matching months of the year were considered as control. A comparison of the effect of COVID 19 on the severity of AP was done by measuring Glasgow and revised Atlanta scores. Results: 37 cases of COVID 19 patients developed AP in this study. The serum calcium, and albumin were lower, while blood urea, sugar, and Glasgow score all were higher in cases of COVID 19 than control. Follow up, showed that 17 (19.5%) of the cases developed severe pancreatitis, 76.5% of severe cases of AP had COVID 19 on comparison to control. COVID 19 is an independent predictor for severity of AP. Conclusions: COVID 19 is an independent predictor for severity of AP. More directed care to the cases of COVID 19 with superimposed AP, as they prone to develop severe form. Future studies to examine the effect of COVID 19 antiviral therapy on the severity of AP is recommended. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1131Acute pancreatitisCoronavirusesAtlanta scoreGlasgow scoreamylase |
| spellingShingle | Kamal Al-Jawdah Furat Abdulhussein Aboodi Qasem Abdulzahra Al Behadili Muthana Haroon The Effect of COVID-19 Infection on Severity of Acute Pancreatitis: A Prospective Cohort Study مجله كليه طب الكندي Acute pancreatitis Coronaviruses Atlanta score Glasgow score amylase |
| title | The Effect of COVID-19 Infection on Severity of Acute Pancreatitis: A Prospective Cohort Study |
| title_full | The Effect of COVID-19 Infection on Severity of Acute Pancreatitis: A Prospective Cohort Study |
| title_fullStr | The Effect of COVID-19 Infection on Severity of Acute Pancreatitis: A Prospective Cohort Study |
| title_full_unstemmed | The Effect of COVID-19 Infection on Severity of Acute Pancreatitis: A Prospective Cohort Study |
| title_short | The Effect of COVID-19 Infection on Severity of Acute Pancreatitis: A Prospective Cohort Study |
| title_sort | effect of covid 19 infection on severity of acute pancreatitis a prospective cohort study |
| topic | Acute pancreatitis Coronaviruses Atlanta score Glasgow score amylase |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1131 |
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