Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review
Background: Vertical transmission of Zika Virus (ZIKV) can be associated with several clinical features in newborn infants. The goal of the present review was to analyze the current state of knowledge regarding clinical repercussions following perinatal exposure to ZIKV in children up to 3 years of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.699115/full |
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| author | Yasmin Notarbartolo di Villarosa do Amaral Jocieli Malacarne Paloma Glauca Brandão Patrícia Brasil Karin Nielsen-Saines Maria Elisabeth Lopes Moreira |
| author_facet | Yasmin Notarbartolo di Villarosa do Amaral Jocieli Malacarne Paloma Glauca Brandão Patrícia Brasil Karin Nielsen-Saines Maria Elisabeth Lopes Moreira |
| author_sort | Yasmin Notarbartolo di Villarosa do Amaral |
| collection | DOAJ |
| description | Background: Vertical transmission of Zika Virus (ZIKV) can be associated with several clinical features in newborn infants. The goal of the present review was to analyze the current state of knowledge regarding clinical repercussions following perinatal exposure to ZIKV in children up to 3 years of age.Methods: A systematic review of published studies was carried out, without the restriction of language or date of publication, identified in the databases PubMed, Virtual Health Library (BVS), Scopus, and Web of Science and the catalog for CAPES theses and dissertations. According to the proposed flowchart, the bibliographic search resulted in 1,563 papers. Of these, according to the eligibility criteria, 70 were selected for systematic review; all were published between 2016 and 2021.Results: Regarding clinical findings, 19 papers evaluated clinical imaging alterations, 21 ophthalmic manifestations, and 39 evaluated the central nervous system; of these, 15 analyzed neuro-psychomotor development. The remainder evaluated audiological (n = 14), nutritional (n = 14), orthopedic (n = 7), cardiorespiratory (n = 5), genitourinary (n = 3) or endocrinological (n = 1) manifestations.Conclusion: It is critical for studies to continue monitoring children with antenatal ZIKV exposure as they grow, given the unknown long-term repercussions of ZIKV and the recognized postnatal complications of this infection during pregnancy. Broader descriptions of observed clinical findings are also important in order to characterize the entire spectrum of disease in children.Systematic Review Registration: PROSPERO REGISTER: CRD42020205947. |
| first_indexed | 2024-12-16T12:09:38Z |
| format | Article |
| id | doaj.art-11cc3781f59c4296a03fdb7d082b91c9 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-16T12:09:38Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-11cc3781f59c4296a03fdb7d082b91c92022-12-21T22:32:14ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-08-011210.3389/fpsyt.2021.699115699115Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic ReviewYasmin Notarbartolo di Villarosa do Amaral0Jocieli Malacarne1Paloma Glauca Brandão2Patrícia Brasil3Karin Nielsen-Saines4Maria Elisabeth Lopes Moreira5Department of Pediatrics, Instituto Fernandes Figueira, Rio de Janeiro, BrazilDepartment of Pediatrics, Instituto Fernandes Figueira, Rio de Janeiro, BrazilDepartment of Pediatrics, Instituto Fernandes Figueira, Rio de Janeiro, BrazilDepartment of Acute Febrile Illnesses, Instituto Nacional de Infectologia, Rio de Janeiro, BrazilDepartment of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Pediatrics, Instituto Fernandes Figueira, Rio de Janeiro, BrazilBackground: Vertical transmission of Zika Virus (ZIKV) can be associated with several clinical features in newborn infants. The goal of the present review was to analyze the current state of knowledge regarding clinical repercussions following perinatal exposure to ZIKV in children up to 3 years of age.Methods: A systematic review of published studies was carried out, without the restriction of language or date of publication, identified in the databases PubMed, Virtual Health Library (BVS), Scopus, and Web of Science and the catalog for CAPES theses and dissertations. According to the proposed flowchart, the bibliographic search resulted in 1,563 papers. Of these, according to the eligibility criteria, 70 were selected for systematic review; all were published between 2016 and 2021.Results: Regarding clinical findings, 19 papers evaluated clinical imaging alterations, 21 ophthalmic manifestations, and 39 evaluated the central nervous system; of these, 15 analyzed neuro-psychomotor development. The remainder evaluated audiological (n = 14), nutritional (n = 14), orthopedic (n = 7), cardiorespiratory (n = 5), genitourinary (n = 3) or endocrinological (n = 1) manifestations.Conclusion: It is critical for studies to continue monitoring children with antenatal ZIKV exposure as they grow, given the unknown long-term repercussions of ZIKV and the recognized postnatal complications of this infection during pregnancy. Broader descriptions of observed clinical findings are also important in order to characterize the entire spectrum of disease in children.Systematic Review Registration: PROSPERO REGISTER: CRD42020205947.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.699115/fullzika virussystematic reviewneurological repercussionclinical repercussionneurodevelopment |
| spellingShingle | Yasmin Notarbartolo di Villarosa do Amaral Jocieli Malacarne Paloma Glauca Brandão Patrícia Brasil Karin Nielsen-Saines Maria Elisabeth Lopes Moreira Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review Frontiers in Psychiatry zika virus systematic review neurological repercussion clinical repercussion neurodevelopment |
| title | Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review |
| title_full | Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review |
| title_fullStr | Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review |
| title_full_unstemmed | Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review |
| title_short | Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review |
| title_sort | time to evaluate the clinical repercussions of zika virus vertical transmission a systematic review |
| topic | zika virus systematic review neurological repercussion clinical repercussion neurodevelopment |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.699115/full |
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