Efficacy of Afatinib in the Treatment of Patients with Non-Small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Efficacy of Afatinib in the Treatment of Patients with Non-Small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Several randomized controlled trials (RCTs) evaluated the afatinib efficacy in patients with advanced non-small cell lung cancer (NSCLC) and recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). This review systemically outlined and meta-analyzed the afatinib efficacy in NSCLC and...

Full description

Bibliographic Details
Main Authors:	Nian N. N. Maarof, Abdulsamad Alsalahi, Emilia Abdulmalek, Sharida Fakurazi, Bimo Ario Tejo, Mohd Basyaruddin Abdul Rahman
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Cancers
Subjects:	afatinib randomized clinical trials non-small cell lung cancer head and neck squamous cell carcinoma
Online Access:	https://www.mdpi.com/2072-6694/13/4/688

Similar Items

Efficacy of Afatinib in the treatment of patients with non-small cell lung cancer and head and neck squamous cell carcinoma: a systematic review and meta-analysis
by: Maarof, Nian N. N., et al.
Published: (2021)

Appropriate Sequence for Afatinib and Cisplatin Combination Improves Anticancer Activity in Head and Neck Squamous Cell Carcinoma
by: Eleonore Longton, et al.
Published: (2018-10-01)

Biodegradable Carbonate Apatite Nanoparticle as a Delivery System to Promote Afatinib Delivery for Non-Small Cell Lung Cancer Treatment
by: Nian N. N. Maarof, et al.
Published: (2022-06-01)

Short-course pembrolizumab and continuous afatinib therapy for recurrent or metastatic head and neck squamous cell carcinoma: a real-world data analysis
by: Hsiang-Fong Kao, et al.
Published: (2022-11-01)

Role of afatinib in the treatment of advanced lung squamous cell carcinoma
by: Vavalà T
Published: (2017-11-01)

Simultaneous targeting of EGFR, HER2, and HER4 by afatinib overcomes intrinsic and acquired cetuximab resistance in head and neck squamous cell carcinoma cell lines
by: Ines De Pauw, et al.
Published: (2018-06-01)

Real-world effectiveness of second-line Afatinib versus chemotherapy for the treatment of advanced lung squamous cell carcinoma in immunotherapy-naïve patients
by: You-Yi Chen, et al.
Published: (2021-11-01)

Second-line afatinib administration in an elderly patient with squamous cell carcinoma
by: Hohenforst-Schmidt W, et al.
Published: (2017-03-01)

Real-World Treatment Outcomes and Safety of Afatinib in Advanced Squamous Cell Lung Cancer Progressed after Platinum-Based Doublet Chemotherapy and Immunotherapy (SPACE Study)
by: Wonjun Ji, et al.
Published: (2023-11-01)

Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far
by: Xu Y, et al.
Published: (2016-05-01)

Treatment outcomes and safety of afatinib in advanced squamous cell lung cancer progressed after platinum‐based doublet chemotherapy and immunotherapy (SPACE study)
by: Seung Hyeun Lee, et al.
Published: (2021-04-01)

Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung: Final analysis of the randomised phase 3 LUX-Lung 8 trial
by: Glenwood D. Goss, et al.
Published: (2021-07-01)

Biodegradable carbonate apatite nanoparticle as a delivery system to promote afatinib delivery for non-small cell lung cancer treatment
by: Maarof, Nian N. N., et al.
Published: (2022)

Basaloid squamous cell carcinoma of the head and neck: Our experience
by: Jaimanti Bakshi, et al.
Published: (2020-01-01)

Sarcopenia as a predictor of initial administration dose of afatinib in patients with advanced non‐small cell lung cancer
by: Xin Nie, et al.
Published: (2021-06-01)

Efficacy and dose of afatinib in patients with non‐small cell lung cancer after failure of prior gefitinib or erlotinib treatment
by: Hayoung Choi, et al.
Published: (2021-05-01)

MicroRNAs in Head and Neck Squamous Cell Carcinoma (HNSCC) and Oral Squamous Cell Carcinoma (OSCC)
by: Masashi Shiiba, et al.
Published: (2010-04-01)

Afatinib-induced acneiform eruptions
by: Twinkle Singh Thakur, et al.
Published: (2022-01-01)

Factors influencing outcomes in selective neck dissection in 661 patients with head and neck squamous cell carcinoma
by: Mattis Bertlich, et al.
Published: (2022-05-01)

Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report
by: Jun Nishimura, et al.
Published: (2017-07-01)

Evaluating the cost-effectiveness of afatinib after platinum-based therapy for the treatment of squamous non-small-cell lung cancer in France
by: Pignata M, et al.
Published: (2017-10-01)

DISEASE RECURRENCE PREDICTORS FOR PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA
by: Yuniardini S. Wimardhani, et al.
Published: (2015-06-01)

Tumor Microenvironment in Head and Neck Squamous Cell Carcinomas
by: Görkem Eskiizmir
Published: (2015-09-01)

Afatinib treatment response in advanced lung adenocarcinomas harboring uncommon mutations
by: Teng Li, et al.
Published: (2021-11-01)

Afatinib Mediates Autophagic Degradation of ORAI1, STIM1, and SERCA2, Which Inhibits Proliferation of Non–Small Cell Lung Cancer Cells
by: Mi Seong Kim, et al.
Published: (2022-04-01)

Afatinib Sensibilizes Multidrug-resistant Human Ovarian Cancer Cells to Adriamycin and Related Mechanisms
by: ZHANG Yunqi, et al.
Published: (2018-10-01)

The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma
by: Shengjian Jin, et al.
Published: (2022-12-01)

Stimulation of Eryptosis by Afatinib
by: Abdulla Al Mamun Bhuyan, et al.
Published: (2018-06-01)

Epidemiology of head and neck squamous cell carcinoma in birjand city, between 2008 and 2017
by: Leili Alizadeh, et al.
Published: (2019-07-01)

Single-Cell Deconvolution of Head and Neck Squamous Cell Carcinoma
by: Zongtai Qi, et al.
Published: (2021-03-01)

MAPKs activation in head and neck squamous cell carcinomas
by: Daniele Maggioni, et al.
Published: (2011-11-01)

Correlation between T and N Stages of Head and Neck Squamous Cell Carcinoma
by: Krishna Koirala, et al.
Published: (2015-07-01)

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
by: Raghupathy Vengoji, et al.
Published: (2019-06-01)

A real-world study of Afatinib plus ramucirumab in treatment-naïve, EGFR-mutated, non–small cell lung cancer
by: Chun-Yao Huang, et al.
Published: (2023-05-01)

Central neck lymph node metastasis in oral squamous cell carcinoma at the floor of mouth
by: Songtao Zhang, et al.
Published: (2021-03-01)

Correlation of Tissue Eosinophils with Prognosis in Head and Neck Cutaneous Squamous Cell Carcinomas
by: javad halimi, et al.
Published: (2018-10-01)

ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study
by: Zielinski Valerie, et al.
Published: (2012-02-01)

DNA methylation biomarkers for head and neck squamous cell carcinoma
by: Chongchang Zhou, et al.
Published: (2018-04-01)

Neck management in metastatic cutaneous squamous cell carcinoma of the head and neck
by: Ning Xu, et al.
Published: (2024-02-01)

Current status and perspective of tumor immunotherapy for head and neck squamous cell carcinoma
by: Chenhang Yu, et al.
Published: (2022-08-01)