Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases
Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide. In 2022, the CVDs contributed to 19.8 million deaths globally, accounting for one-third of all global deaths. With an aging population and changing lifestyles, CVDs pose a major threat to human health. Mitochondria-as...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1398381/full |
| _version_ | 1797203141350916096 |
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| author | Yanqiu Ding Yanqiu Ding Nanyang Liu Dawu Zhang Dawu Zhang Lijun Guo Qinghua Shang Yicheng Liu Gaocan Ren Xiaochang Ma Xiaochang Ma |
| author_facet | Yanqiu Ding Yanqiu Ding Nanyang Liu Dawu Zhang Dawu Zhang Lijun Guo Qinghua Shang Yicheng Liu Gaocan Ren Xiaochang Ma Xiaochang Ma |
| author_sort | Yanqiu Ding |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide. In 2022, the CVDs contributed to 19.8 million deaths globally, accounting for one-third of all global deaths. With an aging population and changing lifestyles, CVDs pose a major threat to human health. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are communication platforms between cellular organelles and regulate cellular physiological functions, including apoptosis, autophagy, and programmed necrosis. Further research has shown that MAMs play a critical role in the pathogenesis of CVDs, including myocardial ischemia and reperfusion injury, heart failure, pulmonary hypertension, and coronary atherosclerosis. This suggests that MAMs could be an important therapeutic target for managing CVDs. The goal of this study is to summarize the protein complex of MAMs, discuss its role in the pathological mechanisms of CVDs in terms of its functions such as Ca2+ transport, apoptotic signaling, and lipid metabolism, and suggest the possibility of MAMs as a potential therapeutic approach. |
| first_indexed | 2024-04-24T08:14:37Z |
| format | Article |
| id | doaj.art-11ce101561c04be3a1520f177ed3ff19 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-24T08:14:37Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-11ce101561c04be3a1520f177ed3ff192024-04-17T04:22:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-04-011510.3389/fphar.2024.13983811398381Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseasesYanqiu Ding0Yanqiu Ding1Nanyang Liu2Dawu Zhang3Dawu Zhang4Lijun Guo5Qinghua Shang6Yicheng Liu7Gaocan Ren8Xiaochang Ma9Xiaochang Ma10Cardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Geratology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCardiovascular diseases (CVDs) are currently the leading cause of death worldwide. In 2022, the CVDs contributed to 19.8 million deaths globally, accounting for one-third of all global deaths. With an aging population and changing lifestyles, CVDs pose a major threat to human health. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are communication platforms between cellular organelles and regulate cellular physiological functions, including apoptosis, autophagy, and programmed necrosis. Further research has shown that MAMs play a critical role in the pathogenesis of CVDs, including myocardial ischemia and reperfusion injury, heart failure, pulmonary hypertension, and coronary atherosclerosis. This suggests that MAMs could be an important therapeutic target for managing CVDs. The goal of this study is to summarize the protein complex of MAMs, discuss its role in the pathological mechanisms of CVDs in terms of its functions such as Ca2+ transport, apoptotic signaling, and lipid metabolism, and suggest the possibility of MAMs as a potential therapeutic approach.https://www.frontiersin.org/articles/10.3389/fphar.2024.1398381/fullcardiovascular diseasesmitochondria-associated endoplasmic reticulum membranetherapeutic targetcoronary atherosclerosismyocardial ischemia |
| spellingShingle | Yanqiu Ding Yanqiu Ding Nanyang Liu Dawu Zhang Dawu Zhang Lijun Guo Qinghua Shang Yicheng Liu Gaocan Ren Xiaochang Ma Xiaochang Ma Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases Frontiers in Pharmacology cardiovascular diseases mitochondria-associated endoplasmic reticulum membrane therapeutic target coronary atherosclerosis myocardial ischemia |
| title | Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases |
| title_full | Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases |
| title_fullStr | Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases |
| title_full_unstemmed | Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases |
| title_short | Mitochondria-associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases |
| title_sort | mitochondria associated endoplasmic reticulum membranes as a therapeutic target for cardiovascular diseases |
| topic | cardiovascular diseases mitochondria-associated endoplasmic reticulum membrane therapeutic target coronary atherosclerosis myocardial ischemia |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1398381/full |
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