Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

ZRANB1 (human Trabid) missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how Trabid regulates neurodevelopment is not understood. We have characterized these patient mutations in cells and mice to identify a key role f...

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Main Authors: Daniel Frank, Maria Bergamasco, Michael J Mlodzianoski, Andrew Kueh, Ellen Tsui, Cathrine Hall, Georgios Kastrappis, Anne Kathrin Voss, Catriona McLean, Maree Faux, Kelly L Rogers, Bang Tran, Elizabeth Vincan, David Komander, Grant Dewson, Hoanh Tran
格式: Article
語言:English
出版: eLife Sciences Publications Ltd 2023-12-01
叢編:eLife
主題:
adenomatous polyposis coli
neurodevelopment
ZRANB1
Trabid
STRIPAK
axonal protein trafficking
在線閱讀:https://elifesciences.org/articles/90796

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https://elifesciences.org/articles/90796

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