Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth
ZRANB1 (human Trabid) missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how Trabid regulates neurodevelopment is not understood. We have characterized these patient mutations in cells and mice to identify a key role f...
Hoofdauteurs: | , , , , , , , , , , , , , , , |
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Formaat: | Artikel |
Taal: | English |
Gepubliceerd in: |
eLife Sciences Publications Ltd
2023-12-01
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Reeks: | eLife |
Onderwerpen: | |
Online toegang: | https://elifesciences.org/articles/90796 |