Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

ZRANB1 (human Trabid) missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how Trabid regulates neurodevelopment is not understood. We have characterized these patient mutations in cells and mice to identify a key role f...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs: Daniel Frank, Maria Bergamasco, Michael J Mlodzianoski, Andrew Kueh, Ellen Tsui, Cathrine Hall, Georgios Kastrappis, Anne Kathrin Voss, Catriona McLean, Maree Faux, Kelly L Rogers, Bang Tran, Elizabeth Vincan, David Komander, Grant Dewson, Hoanh Tran
Formaat: Artikel
Taal:English
Gepubliceerd in: eLife Sciences Publications Ltd 2023-12-01
Reeks:eLife
Onderwerpen:
Online toegang:https://elifesciences.org/articles/90796