An integrated approach to assess the complications of deforming osteoarthritis in sports medicine
Objective: prognosis of thromboembolic complications using clinical diagnostic markers.Materials and methods. The study involved 151 patients who underwent total arthroplasty (TA) of large joints of the lower extremities. Blood serum was studied at the patient’s admission to the hospital, after surg...
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| Format: | Article |
| Language: | English |
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National Electronic Information Consortium (NEICON)
2021-03-01
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| Series: | Спортивная медицина: наука и практика |
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| Online Access: | https://www.smjournal.ru/jour/article/view/236 |
| _version_ | 1797372485053710336 |
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| author | I. S. Vorobyova V. B. Borodulin V. V. Nikitina |
| author_facet | I. S. Vorobyova V. B. Borodulin V. V. Nikitina |
| author_sort | I. S. Vorobyova |
| collection | DOAJ |
| description | Objective: prognosis of thromboembolic complications using clinical diagnostic markers.Materials and methods. The study involved 151 patients who underwent total arthroplasty (TA) of large joints of the lower extremities. Blood serum was studied at the patient’s admission to the hospital, after surgery, and at discharge from the hospital. The following parameters were determined: cell-molecular marker vascular endothelial growth factor (VEGF), a genetic study was performed using the “Plasma screen. Plasma factors of the blood clotting system”. The content of VEGF was determined in blood serum using solid-phase enzyme immunoassay. The effectiveness of diagnostics based on sensitivity and specificity analysis was considered by constructing a ROC analysis at different points of separation of the values of the studied indicators.Results. Diagnostic significance of VEGF and the efficiency of determining PAI-1 were determined. In patients with elevated VEGF values (>183.6 pg/ml), PAI-1 gene polymorphism was detected, which reduces the fibrinolytic activity of the blood system and increases the risk of coronary disorders. This is especially important for patients in a hospital with a large number of risk factors for the development of VTEC due to prolonged immobilization of the limb. The study made it possible to determine that with VEGF values up to 183.6 pg/ml, a low probability of thromboembolic complications is predicted, and with values above 183.6 pg/ml — high.Conclusion. The course of DOA in athletes may be complicated by surgical intra-articular interventions of traumatological and orthopedic profile, which does not exclude the development of VTEO, significantly complicating drug therapy and the rehabilitation period. The presented data show that the determination of VEGF, 5G-675 4G polymorphism of the PAI 1 gene in blood serum can be used to assess the risk of venous thromboembolic complications (VTE), contributing to modern informative diagnostics, improving the quality of life of athletes and prolonging their sports career. |
| first_indexed | 2024-03-08T18:36:30Z |
| format | Article |
| id | doaj.art-11cfff02502d4f7fa3e1db4824f86663 |
| institution | Directory Open Access Journal |
| issn | 2223-2524 2587-9014 |
| language | English |
| last_indexed | 2024-03-08T18:36:30Z |
| publishDate | 2021-03-01 |
| publisher | National Electronic Information Consortium (NEICON) |
| record_format | Article |
| series | Спортивная медицина: наука и практика |
| spelling | doaj.art-11cfff02502d4f7fa3e1db4824f866632023-12-29T11:27:47ZengNational Electronic Information Consortium (NEICON)Спортивная медицина: наука и практика2223-25242587-90142021-03-01104152110.47529/2223-2524.2020.4.8225An integrated approach to assess the complications of deforming osteoarthritis in sports medicineI. S. Vorobyova0V. B. Borodulin1V. V. Nikitina2Saratov State Medical University named after V. I. RazumovskySaratov State Medical University named after V. I. RazumovskySaratov State Medical University named after V. I. RazumovskyObjective: prognosis of thromboembolic complications using clinical diagnostic markers.Materials and methods. The study involved 151 patients who underwent total arthroplasty (TA) of large joints of the lower extremities. Blood serum was studied at the patient’s admission to the hospital, after surgery, and at discharge from the hospital. The following parameters were determined: cell-molecular marker vascular endothelial growth factor (VEGF), a genetic study was performed using the “Plasma screen. Plasma factors of the blood clotting system”. The content of VEGF was determined in blood serum using solid-phase enzyme immunoassay. The effectiveness of diagnostics based on sensitivity and specificity analysis was considered by constructing a ROC analysis at different points of separation of the values of the studied indicators.Results. Diagnostic significance of VEGF and the efficiency of determining PAI-1 were determined. In patients with elevated VEGF values (>183.6 pg/ml), PAI-1 gene polymorphism was detected, which reduces the fibrinolytic activity of the blood system and increases the risk of coronary disorders. This is especially important for patients in a hospital with a large number of risk factors for the development of VTEC due to prolonged immobilization of the limb. The study made it possible to determine that with VEGF values up to 183.6 pg/ml, a low probability of thromboembolic complications is predicted, and with values above 183.6 pg/ml — high.Conclusion. The course of DOA in athletes may be complicated by surgical intra-articular interventions of traumatological and orthopedic profile, which does not exclude the development of VTEO, significantly complicating drug therapy and the rehabilitation period. The presented data show that the determination of VEGF, 5G-675 4G polymorphism of the PAI 1 gene in blood serum can be used to assess the risk of venous thromboembolic complications (VTE), contributing to modern informative diagnostics, improving the quality of life of athletes and prolonging their sports career.https://www.smjournal.ru/jour/article/view/236sportdeforming osteoarthritisgenetic polymorphismsvegfpai-1thromboembolic complications |
| spellingShingle | I. S. Vorobyova V. B. Borodulin V. V. Nikitina An integrated approach to assess the complications of deforming osteoarthritis in sports medicine Спортивная медицина: наука и практика sport deforming osteoarthritis genetic polymorphisms vegf pai-1 thromboembolic complications |
| title | An integrated approach to assess the complications of deforming osteoarthritis in sports medicine |
| title_full | An integrated approach to assess the complications of deforming osteoarthritis in sports medicine |
| title_fullStr | An integrated approach to assess the complications of deforming osteoarthritis in sports medicine |
| title_full_unstemmed | An integrated approach to assess the complications of deforming osteoarthritis in sports medicine |
| title_short | An integrated approach to assess the complications of deforming osteoarthritis in sports medicine |
| title_sort | integrated approach to assess the complications of deforming osteoarthritis in sports medicine |
| topic | sport deforming osteoarthritis genetic polymorphisms vegf pai-1 thromboembolic complications |
| url | https://www.smjournal.ru/jour/article/view/236 |
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