Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia
Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873190/?tool=EBI |
| _version_ | 1797942923596136448 |
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| author | Madeline R. Scott Wei Zong Kyle D. Ketchesin Marianne L. Seney George C. Tseng Bokai Zhu Colleen A. McClung |
| author_facet | Madeline R. Scott Wei Zong Kyle D. Ketchesin Marianne L. Seney George C. Tseng Bokai Zhu Colleen A. McClung |
| author_sort | Madeline R. Scott |
| collection | DOAJ |
| description | Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes. |
| first_indexed | 2024-04-10T20:16:19Z |
| format | Article |
| id | doaj.art-11d0eed8e2854161b9ebe473ec5f6fe8 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-04-10T20:16:19Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-11d0eed8e2854161b9ebe473ec5f6fe82023-01-26T05:31:15ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-01-01211Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophreniaMadeline R. ScottWei ZongKyle D. KetchesinMarianne L. SeneyGeorge C. TsengBokai ZhuColleen A. McClungTwelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873190/?tool=EBI |
| spellingShingle | Madeline R. Scott Wei Zong Kyle D. Ketchesin Marianne L. Seney George C. Tseng Bokai Zhu Colleen A. McClung Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia PLoS Biology |
| title | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia |
| title_full | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia |
| title_fullStr | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia |
| title_full_unstemmed | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia |
| title_short | Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia |
| title_sort | twelve hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873190/?tool=EBI |
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