Immunogenicity of Wild Type and Mutant Hepatitis B Surface Antigen Virus-like Particles (VLPs) in Mice with Pre-Existing Immunity against the Wild Type Vector

Immunogenicity of Wild Type and Mutant Hepatitis B Surface Antigen Virus-like Particles (VLPs) in Mice with Pre-Existing Immunity against the Wild Type Vector

Virus-like particles (VLPs), composed of the small hepatitis B virus surface antigen (HBsAgS), are the antigenic components of the hepatitis B virus (HBV) vaccine and represent the backbones for a chimeric anti-malaria vaccine and various vaccine candidates. Biological vectors have to face pre-exist...

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Bibliographic Details
Main Authors: Natalie J. Kingston, Renae Walsh, Rachel Hammond, Carina C. D. Joe, George Lovrecz, Stephen Locarnini, Hans J. Netter
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
vectored vaccines
delivery platforms
immune sensitization
hepatitis B surface antigen (HBsAg)
Online Access:https://www.mdpi.com/1999-4915/15/2/313

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