Cembranolides and Related Constituents from the Soft Coral <i>Sarcophyton cinereum</i>
In an attempt to explore the bioactive metabolites of the soft coral <i>Sarcophyton cinereum</i>, three new cembranolides, cinerenolides A–C (<b>1</b>–<b>3</b>), and 16 known compounds were isolated and identified from the EtOAc extract. The structures of the new...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/6/1760 |
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| author | Chih-Hua Chao Yi-Ju Chen Chiung-Yao Huang Fang-Rong Chang Chang-Feng Dai Jyh-Horng Sheu |
| author_facet | Chih-Hua Chao Yi-Ju Chen Chiung-Yao Huang Fang-Rong Chang Chang-Feng Dai Jyh-Horng Sheu |
| author_sort | Chih-Hua Chao |
| collection | DOAJ |
| description | In an attempt to explore the bioactive metabolites of the soft coral <i>Sarcophyton cinereum</i>, three new cembranolides, cinerenolides A–C (<b>1</b>–<b>3</b>), and 16 known compounds were isolated and identified from the EtOAc extract. The structures of the new cembranolides were elucidated on the basis of spectroscopic analysis, and the NOE analysis of cinerenolide A (<b>1</b>) was performed with the assistance of the calculated lowest-energy molecular model. The relative configuration of cinerenolide C (<b>3</b>) was determined by the quantum chemical NMR calculation, followed by applying DP4+ analysis. In addition, the cytotoxic assays disclosed that some compounds exhibited moderate to potent activities in the proliferation of P388, DLD-1, HuCCT-1, and CCD966SK cell lines. |
| first_indexed | 2024-03-09T13:11:15Z |
| format | Article |
| id | doaj.art-11d6e26aef9b46b3ba99eab43c1abbaf |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T13:11:15Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-11d6e26aef9b46b3ba99eab43c1abbaf2023-11-30T21:40:45ZengMDPI AGMolecules1420-30492022-03-01276176010.3390/molecules27061760Cembranolides and Related Constituents from the Soft Coral <i>Sarcophyton cinereum</i>Chih-Hua Chao0Yi-Ju Chen1Chiung-Yao Huang2Fang-Rong Chang3Chang-Feng Dai4Jyh-Horng Sheu5School of Pharmacy, China Medical University, Taichung 406040, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, TaiwanInstitute of Oceanography, National Taiwan University, Taipei 10617, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, TaiwanIn an attempt to explore the bioactive metabolites of the soft coral <i>Sarcophyton cinereum</i>, three new cembranolides, cinerenolides A–C (<b>1</b>–<b>3</b>), and 16 known compounds were isolated and identified from the EtOAc extract. The structures of the new cembranolides were elucidated on the basis of spectroscopic analysis, and the NOE analysis of cinerenolide A (<b>1</b>) was performed with the assistance of the calculated lowest-energy molecular model. The relative configuration of cinerenolide C (<b>3</b>) was determined by the quantum chemical NMR calculation, followed by applying DP4+ analysis. In addition, the cytotoxic assays disclosed that some compounds exhibited moderate to potent activities in the proliferation of P388, DLD-1, HuCCT-1, and CCD966SK cell lines.https://www.mdpi.com/1420-3049/27/6/1760<i>Sarcophyton cinereum</i>cinerenolides A–Dcytotoxityα,β-unsaturated ε-lactone |
| spellingShingle | Chih-Hua Chao Yi-Ju Chen Chiung-Yao Huang Fang-Rong Chang Chang-Feng Dai Jyh-Horng Sheu Cembranolides and Related Constituents from the Soft Coral <i>Sarcophyton cinereum</i> Molecules <i>Sarcophyton cinereum</i> cinerenolides A–D cytotoxity α,β-unsaturated ε-lactone |
| title | Cembranolides and Related Constituents from the Soft Coral <i>Sarcophyton cinereum</i> |
| title_full | Cembranolides and Related Constituents from the Soft Coral <i>Sarcophyton cinereum</i> |
| title_fullStr | Cembranolides and Related Constituents from the Soft Coral <i>Sarcophyton cinereum</i> |
| title_full_unstemmed | Cembranolides and Related Constituents from the Soft Coral <i>Sarcophyton cinereum</i> |
| title_short | Cembranolides and Related Constituents from the Soft Coral <i>Sarcophyton cinereum</i> |
| title_sort | cembranolides and related constituents from the soft coral i sarcophyton cinereum i |
| topic | <i>Sarcophyton cinereum</i> cinerenolides A–D cytotoxity α,β-unsaturated ε-lactone |
| url | https://www.mdpi.com/1420-3049/27/6/1760 |
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