A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study
Abstract Background To explore the postoperative prognosis of esophageal squamous cell carcinoma (ESCC) patients with stage IB/IIA, using a prognostic score (PS). Methods Stage IB/IIA ESCC patients who underwent esophagectomy from 1999 to 2010 were included. We retrospectively recruited 153 patients...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-021-01636-5 |
| _version_ | 1818677069828063232 |
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| author | Lei-Lei Wu Qi-Long Ma Wei Huang Xuan Liu Li-Hong Qiu Peng Lin Hao Long Lan-Jun Zhang Guo-Wei Ma |
| author_facet | Lei-Lei Wu Qi-Long Ma Wei Huang Xuan Liu Li-Hong Qiu Peng Lin Hao Long Lan-Jun Zhang Guo-Wei Ma |
| author_sort | Lei-Lei Wu |
| collection | DOAJ |
| description | Abstract Background To explore the postoperative prognosis of esophageal squamous cell carcinoma (ESCC) patients with stage IB/IIA, using a prognostic score (PS). Methods Stage IB/IIA ESCC patients who underwent esophagectomy from 1999 to 2010 were included. We retrospectively recruited 153 patients and extracted their medical records. Moreover, we analyzed the programmed death ligand-1 (PD-L1) expression of their paraffin tissue. The cohort were randomly divided into a training group (N = 123) and a validation group (N = 30). We selected overall survival (OS) as observed endpoint. Prognostic factors with a multivariable two-sided P < 0.05 met standard of covariate inclusion. Results Univariable and multivariable analyses identified pTNM stage, the number of lymph nodes (NLNs) and PD-L1 expression as independent OS predictors. Primary prognostic score which comprised above three covariates adversely related with OS in two cohorts. PS discrimination of OS was comparable between the training and internal validation cohorts (C-index = 0.774 and 0.801, respectively). In addition, the PS system had an advantage over pTNM stage in the identification of high-risk patients (C-index = 0.774 vs. C-index = 0.570, P < 0.001). Based on PS cutoff, training and validation datasets generated low-risk and high-risk groups with different OS. Our three-factor PS predicted OS (low-risk subgroup vs. high-risk subgroup 60-month OS, 74% vs. 23% for training cohort and 83% vs. 45% for validation cohort). Conclusion Our study suggested a PS for significant clinical stratification of IB/IIA ESCC to screen out subgroups with poor prognosis. |
| first_indexed | 2024-12-17T08:53:31Z |
| format | Article |
| id | doaj.art-11d8037410ed4083b4d4a248f7344be8 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-17T08:53:31Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-11d8037410ed4083b4d4a248f7344be82022-12-21T21:56:00ZengBMCBMC Gastroenterology1471-230X2021-02-0121111010.1186/s12876-021-01636-5A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective studyLei-Lei Wu0Qi-Long Ma1Wei Huang2Xuan Liu3Li-Hong Qiu4Peng Lin5Hao Long6Lan-Jun Zhang7Guo-Wei Ma8Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineJinling HospitalSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineAbstract Background To explore the postoperative prognosis of esophageal squamous cell carcinoma (ESCC) patients with stage IB/IIA, using a prognostic score (PS). Methods Stage IB/IIA ESCC patients who underwent esophagectomy from 1999 to 2010 were included. We retrospectively recruited 153 patients and extracted their medical records. Moreover, we analyzed the programmed death ligand-1 (PD-L1) expression of their paraffin tissue. The cohort were randomly divided into a training group (N = 123) and a validation group (N = 30). We selected overall survival (OS) as observed endpoint. Prognostic factors with a multivariable two-sided P < 0.05 met standard of covariate inclusion. Results Univariable and multivariable analyses identified pTNM stage, the number of lymph nodes (NLNs) and PD-L1 expression as independent OS predictors. Primary prognostic score which comprised above three covariates adversely related with OS in two cohorts. PS discrimination of OS was comparable between the training and internal validation cohorts (C-index = 0.774 and 0.801, respectively). In addition, the PS system had an advantage over pTNM stage in the identification of high-risk patients (C-index = 0.774 vs. C-index = 0.570, P < 0.001). Based on PS cutoff, training and validation datasets generated low-risk and high-risk groups with different OS. Our three-factor PS predicted OS (low-risk subgroup vs. high-risk subgroup 60-month OS, 74% vs. 23% for training cohort and 83% vs. 45% for validation cohort). Conclusion Our study suggested a PS for significant clinical stratification of IB/IIA ESCC to screen out subgroups with poor prognosis.https://doi.org/10.1186/s12876-021-01636-5Esophageal squamous cell carcinomaStage IB/IIALymph nodesPD-L1Prognosis |
| spellingShingle | Lei-Lei Wu Qi-Long Ma Wei Huang Xuan Liu Li-Hong Qiu Peng Lin Hao Long Lan-Jun Zhang Guo-Wei Ma A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study BMC Gastroenterology Esophageal squamous cell carcinoma Stage IB/IIA Lymph nodes PD-L1 Prognosis |
| title | A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study |
| title_full | A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study |
| title_fullStr | A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study |
| title_full_unstemmed | A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study |
| title_short | A prognostic model for stratification of stage IB/IIA esophageal squamous cell carcinoma: a retrospective study |
| title_sort | prognostic model for stratification of stage ib iia esophageal squamous cell carcinoma a retrospective study |
| topic | Esophageal squamous cell carcinoma Stage IB/IIA Lymph nodes PD-L1 Prognosis |
| url | https://doi.org/10.1186/s12876-021-01636-5 |
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