N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism
Type 2 diabetes (T2D) is a metabolic disease with an increasing rate of incidence worldwide. Despite the considerable progress in the prevention and intervention, T2D and its complications cannot be reversed easily after diagnosis, thereby necessitating an in-depth investigation of the pathophysiolo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-07-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1166756/full |
| _version_ | 1797785218373910528 |
|---|---|
| author | Haocheng Zhang Haocheng Zhang Haocheng Zhang Yan Gu Qiaojian Gang Jing Huang Qian Xiao Xiaoqin Ha Xiaoqin Ha Xiaoqin Ha |
| author_facet | Haocheng Zhang Haocheng Zhang Haocheng Zhang Yan Gu Qiaojian Gang Jing Huang Qian Xiao Xiaoqin Ha Xiaoqin Ha Xiaoqin Ha |
| author_sort | Haocheng Zhang |
| collection | DOAJ |
| description | Type 2 diabetes (T2D) is a metabolic disease with an increasing rate of incidence worldwide. Despite the considerable progress in the prevention and intervention, T2D and its complications cannot be reversed easily after diagnosis, thereby necessitating an in-depth investigation of the pathophysiology. In recent years, the role of epigenetics has been increasingly demonstrated in the disease, of which N6-methyladenosine (m6A) is one of the most common post-transcriptional modifications. Interestingly, patients with T2D show a low m6A abundance. Thus, a comprehensive analysis and understanding of this phenomenon would improve our understanding of the pathophysiology, as well as the search for new biomarkers and therapeutic approaches for T2D. In this review, we systematically introduced the metabolic roles of m6A modification in organs, the metabolic signaling pathways involved, and the effects of clinical drugs on T2D. |
| first_indexed | 2024-03-13T00:51:55Z |
| format | Article |
| id | doaj.art-11d931b402a84da29205178befc186fc |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T00:51:55Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-11d931b402a84da29205178befc186fc2023-07-07T12:23:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.11667561166756N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolismHaocheng Zhang0Haocheng Zhang1Haocheng Zhang2Yan Gu3Qiaojian Gang4Jing Huang5Qian Xiao6Xiaoqin Ha7Xiaoqin Ha8Xiaoqin Ha9The Second School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, ChinaDepartment of Clinical Laboratory, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaKey Laboratory of Stem Cells and Gene Drugs of Gansu Province, Lanzhou, Gansu, ChinaCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, ChinaThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, ChinaSchool of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, ChinaSchool of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, ChinaThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, ChinaDepartment of Clinical Laboratory, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou, Gansu, ChinaKey Laboratory of Stem Cells and Gene Drugs of Gansu Province, Lanzhou, Gansu, ChinaType 2 diabetes (T2D) is a metabolic disease with an increasing rate of incidence worldwide. Despite the considerable progress in the prevention and intervention, T2D and its complications cannot be reversed easily after diagnosis, thereby necessitating an in-depth investigation of the pathophysiology. In recent years, the role of epigenetics has been increasingly demonstrated in the disease, of which N6-methyladenosine (m6A) is one of the most common post-transcriptional modifications. Interestingly, patients with T2D show a low m6A abundance. Thus, a comprehensive analysis and understanding of this phenomenon would improve our understanding of the pathophysiology, as well as the search for new biomarkers and therapeutic approaches for T2D. In this review, we systematically introduced the metabolic roles of m6A modification in organs, the metabolic signaling pathways involved, and the effects of clinical drugs on T2D.https://www.frontiersin.org/articles/10.3389/fendo.2023.1166756/fullinsulin resistancemetabolismm6A modificationsignaling pathwaytype 2 diabetes |
| spellingShingle | Haocheng Zhang Haocheng Zhang Haocheng Zhang Yan Gu Qiaojian Gang Jing Huang Qian Xiao Xiaoqin Ha Xiaoqin Ha Xiaoqin Ha N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism Frontiers in Endocrinology insulin resistance metabolism m6A modification signaling pathway type 2 diabetes |
| title | N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism |
| title_full | N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism |
| title_fullStr | N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism |
| title_full_unstemmed | N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism |
| title_short | N6-methyladenosine RNA modification: an emerging molecule in type 2 diabetes metabolism |
| title_sort | n6 methyladenosine rna modification an emerging molecule in type 2 diabetes metabolism |
| topic | insulin resistance metabolism m6A modification signaling pathway type 2 diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1166756/full |
| work_keys_str_mv | AT haochengzhang n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT haochengzhang n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT haochengzhang n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT yangu n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT qiaojiangang n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT jinghuang n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT qianxiao n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT xiaoqinha n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT xiaoqinha n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism AT xiaoqinha n6methyladenosinernamodificationanemergingmoleculeintype2diabetesmetabolism |