Potential role of platelets in COVID‐19: Implications for thrombosis
Abstract For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recogn...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
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| Online Access: | https://doi.org/10.1002/rth2.12397 |
| _version_ | 1797762767292203008 |
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| author | Milka Koupenova |
| author_facet | Milka Koupenova |
| author_sort | Milka Koupenova |
| collection | DOAJ |
| description | Abstract For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019. |
| first_indexed | 2024-03-12T19:33:10Z |
| format | Article |
| id | doaj.art-11da6f3b113e42bdb0bff4813dbf0dd6 |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T19:33:10Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-11da6f3b113e42bdb0bff4813dbf0dd62023-08-02T04:22:01ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792020-07-014573774010.1002/rth2.12397Potential role of platelets in COVID‐19: Implications for thrombosisMilka Koupenova0Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester MA USAAbstract For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019.https://doi.org/10.1002/rth2.12397COVID‐19immunityplateletsSARS‐CoV‐2thrombosis |
| spellingShingle | Milka Koupenova Potential role of platelets in COVID‐19: Implications for thrombosis Research and Practice in Thrombosis and Haemostasis COVID‐19 immunity platelets SARS‐CoV‐2 thrombosis |
| title | Potential role of platelets in COVID‐19: Implications for thrombosis |
| title_full | Potential role of platelets in COVID‐19: Implications for thrombosis |
| title_fullStr | Potential role of platelets in COVID‐19: Implications for thrombosis |
| title_full_unstemmed | Potential role of platelets in COVID‐19: Implications for thrombosis |
| title_short | Potential role of platelets in COVID‐19: Implications for thrombosis |
| title_sort | potential role of platelets in covid 19 implications for thrombosis |
| topic | COVID‐19 immunity platelets SARS‐CoV‐2 thrombosis |
| url | https://doi.org/10.1002/rth2.12397 |
| work_keys_str_mv | AT milkakoupenova potentialroleofplateletsincovid19implicationsforthrombosis |