Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone
Abstract Background What is the right surface for an implant to achieve biological fixation? Surface technologies can play important roles in encouraging interactions between the implant surface and the host bone to achieve osseointegration. Preclinical animal models provide important insight into i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-020-01696-5 |
| _version_ | 1811297862368100352 |
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| author | William Robert Walsh Matthew Henry Pelletier Nicky Bertollo Vedran Lovric Tian Wang Per Morberg William Chase Harington Parr Dario Bergadano |
| author_facet | William Robert Walsh Matthew Henry Pelletier Nicky Bertollo Vedran Lovric Tian Wang Per Morberg William Chase Harington Parr Dario Bergadano |
| author_sort | William Robert Walsh |
| collection | DOAJ |
| description | Abstract Background What is the right surface for an implant to achieve biological fixation? Surface technologies can play important roles in encouraging interactions between the implant surface and the host bone to achieve osseointegration. Preclinical animal models provide important insight into in vivo performance related to bone ongrowth and implant fixation. Methods A large animal model was used to compare the in vivo response of HA and plasma-sprayed titanium coatings in a well-reported adult ovine model to evaluate bone ongrowth in terms of mechanical properties in cortical sites, and histology and histomorphometry in cortical and cancellous sites at 4 and 12 weeks. Results Titanium plasma-sprayed surfaces outperformed the HA-coated samples in push-out testing in cortical sites while both surfaces supported new bone ongrowth and remodeling in cortical and cancellous sites. Conclusions While both HA and Ti plasma provided an osteoconductive surface for bone ongrowth, the Ti plasma provided a more robust bone-implant interface that ideally would be required for load transfer and implant stability in the longer term. |
| first_indexed | 2024-04-13T06:11:20Z |
| format | Article |
| id | doaj.art-11dc3bf5782b4e97840707f9120b8f78 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-13T06:11:20Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-11dc3bf5782b4e97840707f9120b8f782022-12-22T02:59:02ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-05-0115111010.1186/s13018-020-01696-5Bone ongrowth and mechanical fixation of implants in cortical and cancellous boneWilliam Robert Walsh0Matthew Henry Pelletier1Nicky Bertollo2Vedran Lovric3Tian Wang4Per Morberg5William Chase Harington Parr6Dario Bergadano7Surgical and Orthopaedic Research Laboratories (SORL), Prince of Wales Clinical School, UNSW SydneySurgical and Orthopaedic Research Laboratories (SORL), Prince of Wales Clinical School, UNSW SydneySurgical and Orthopaedic Research Laboratories (SORL), Prince of Wales Clinical School, UNSW SydneySurgical and Orthopaedic Research Laboratories (SORL), Prince of Wales Clinical School, UNSW SydneySurgical and Orthopaedic Research Laboratories (SORL), Prince of Wales Clinical School, UNSW SydneyDepartment of Surgical and Perioperative Sciences, Umea UniversitySurgical and Orthopaedic Research Laboratories (SORL), Prince of Wales Clinical School, UNSW SydneyMedacta InternationalAbstract Background What is the right surface for an implant to achieve biological fixation? Surface technologies can play important roles in encouraging interactions between the implant surface and the host bone to achieve osseointegration. Preclinical animal models provide important insight into in vivo performance related to bone ongrowth and implant fixation. Methods A large animal model was used to compare the in vivo response of HA and plasma-sprayed titanium coatings in a well-reported adult ovine model to evaluate bone ongrowth in terms of mechanical properties in cortical sites, and histology and histomorphometry in cortical and cancellous sites at 4 and 12 weeks. Results Titanium plasma-sprayed surfaces outperformed the HA-coated samples in push-out testing in cortical sites while both surfaces supported new bone ongrowth and remodeling in cortical and cancellous sites. Conclusions While both HA and Ti plasma provided an osteoconductive surface for bone ongrowth, the Ti plasma provided a more robust bone-implant interface that ideally would be required for load transfer and implant stability in the longer term.http://link.springer.com/article/10.1186/s13018-020-01696-5Bone ongrowthMechanical propertiesPlasma sprayedHydroxyapatiteAnimal modelHistology |
| spellingShingle | William Robert Walsh Matthew Henry Pelletier Nicky Bertollo Vedran Lovric Tian Wang Per Morberg William Chase Harington Parr Dario Bergadano Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone Journal of Orthopaedic Surgery and Research Bone ongrowth Mechanical properties Plasma sprayed Hydroxyapatite Animal model Histology |
| title | Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone |
| title_full | Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone |
| title_fullStr | Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone |
| title_full_unstemmed | Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone |
| title_short | Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone |
| title_sort | bone ongrowth and mechanical fixation of implants in cortical and cancellous bone |
| topic | Bone ongrowth Mechanical properties Plasma sprayed Hydroxyapatite Animal model Histology |
| url | http://link.springer.com/article/10.1186/s13018-020-01696-5 |
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