ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics

ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics

Abstract Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by NOTCH3 mutations. Typical CADASIL is characterised by subcortical ischemic strokes due to severe arteriopathy and fibrotic thickening of small arteries. Arteriolar vascular smoo...

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Bibliographic Details
Main Authors: Mahmod Panahi, Yoshiki Hase, Xavier Gallart-Palau, Sumonto Mitra, Atsushi Watanabe, Roger C Low, Yumi Yamamoto, Diego Sepulveda-Falla, Atticus H Hainsworth, Masafumi Ihara, Siu Kwan Sze, Matti Viitanen, Homira Behbahani, Raj N Kalaria
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Acta Neuropathologica Communications
Subjects:
CADASIL
Complement
Interleukin 6
Intracellular adhesion molecule
Stroke
Vascular smooth muscle cells
Online Access:https://doi.org/10.1186/s40478-023-01558-1

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