Retinal vessel geometry in patients with idiopathic epiretinal membrane
Abstract We investigated the associations between retinal vascular geometric measurements and idiopathic epiretinal membrane (ERM). Whether changes in retinal vascular geometry are independent of systemic cardiovascular risk factors was also evaluated. This retrospective, cross sectional study inclu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32025-5 |
| _version_ | 1797853832777039872 |
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| author | Eun Kyoung Lee Hye Jee Kim Sang-Yoon Lee Su Jeong Song Hyeong Gon Yu |
| author_facet | Eun Kyoung Lee Hye Jee Kim Sang-Yoon Lee Su Jeong Song Hyeong Gon Yu |
| author_sort | Eun Kyoung Lee |
| collection | DOAJ |
| description | Abstract We investigated the associations between retinal vascular geometric measurements and idiopathic epiretinal membrane (ERM). Whether changes in retinal vascular geometry are independent of systemic cardiovascular risk factors was also evaluated. This retrospective, cross sectional study included 98 patients with idiopathic ERM, and 99 healthy age-matched controls. Quantitative retinal vascular parameters were measured from digital retinal fundus photographs using a semi-automated computer-assisted program. Multivariate logistic regression analyses were performed to evaluate associations between retinal vascular geometric parameters and the presence of idiopathic ERM after adjusting for systemic cardiovascular risk factors. There was no significant difference in the baseline characteristics of the two groups, except that the ERM group had a higher proportion of females than the control group. In multivariate regression analyses, female sex (odds ratio [OR] 0.402; 95% CI 0.196–0.802; P = 0.011), wider retinal venular caliber (OR 16.852; 95% CI 5.384–58.997; P < 0.001) and decreased total fractal dimension (OR 0.156; 95% CI 0.052–0.440; P = 0.001) were associated with idiopathic ERM. Idiopathic ERM was associated with alterations in global retinal microvascular geometric parameters, wider retinal venules, and less complex vascular branching patterns, independent of cardiovascular risk factors. |
| first_indexed | 2024-04-09T19:57:10Z |
| format | Article |
| id | doaj.art-11defebb7b464c668fabf0fcbe38cf01 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T19:57:10Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-11defebb7b464c668fabf0fcbe38cf012023-04-03T05:23:30ZengNature PortfolioScientific Reports2045-23222023-03-011311710.1038/s41598-023-32025-5Retinal vessel geometry in patients with idiopathic epiretinal membraneEun Kyoung Lee0Hye Jee Kim1Sang-Yoon Lee2Su Jeong Song3Hyeong Gon Yu4Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University HospitalDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University HospitalSeoul Shinsegae Eye ClinicDepartment of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University HospitalAbstract We investigated the associations between retinal vascular geometric measurements and idiopathic epiretinal membrane (ERM). Whether changes in retinal vascular geometry are independent of systemic cardiovascular risk factors was also evaluated. This retrospective, cross sectional study included 98 patients with idiopathic ERM, and 99 healthy age-matched controls. Quantitative retinal vascular parameters were measured from digital retinal fundus photographs using a semi-automated computer-assisted program. Multivariate logistic regression analyses were performed to evaluate associations between retinal vascular geometric parameters and the presence of idiopathic ERM after adjusting for systemic cardiovascular risk factors. There was no significant difference in the baseline characteristics of the two groups, except that the ERM group had a higher proportion of females than the control group. In multivariate regression analyses, female sex (odds ratio [OR] 0.402; 95% CI 0.196–0.802; P = 0.011), wider retinal venular caliber (OR 16.852; 95% CI 5.384–58.997; P < 0.001) and decreased total fractal dimension (OR 0.156; 95% CI 0.052–0.440; P = 0.001) were associated with idiopathic ERM. Idiopathic ERM was associated with alterations in global retinal microvascular geometric parameters, wider retinal venules, and less complex vascular branching patterns, independent of cardiovascular risk factors.https://doi.org/10.1038/s41598-023-32025-5 |
| spellingShingle | Eun Kyoung Lee Hye Jee Kim Sang-Yoon Lee Su Jeong Song Hyeong Gon Yu Retinal vessel geometry in patients with idiopathic epiretinal membrane Scientific Reports |
| title | Retinal vessel geometry in patients with idiopathic epiretinal membrane |
| title_full | Retinal vessel geometry in patients with idiopathic epiretinal membrane |
| title_fullStr | Retinal vessel geometry in patients with idiopathic epiretinal membrane |
| title_full_unstemmed | Retinal vessel geometry in patients with idiopathic epiretinal membrane |
| title_short | Retinal vessel geometry in patients with idiopathic epiretinal membrane |
| title_sort | retinal vessel geometry in patients with idiopathic epiretinal membrane |
| url | https://doi.org/10.1038/s41598-023-32025-5 |
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