The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases.

The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases.

Sirtuins are a family of phylogenetically conserved nicotinamide adenine dinucleotide-dependent deacetylases that have a firmly established role in aging. Using a simple Saccharomyces cerevisiae yeast heterochromatic derepression assay, we tested a number of environmental chemicals to address the po...

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Bibliographic Details
Main Authors:	Andrew J Olaharski, Jasper Rine, Brett L Marshall, Joshua Babiarz, Luoping Zhang, Eric Verdin, Martyn T Smith
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2005-12-01
Series:	PLoS Genetics
Online Access:	http://europepmc.org/articles/PMC1315280?pdf=render

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