Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research
Blood vessel sprouting from pre-existing vessels or angiogenesis plays a significant role in tumour progression. Development of novel biomolecules from marine natural sources has a promising role in drug discovery specifically in the area of antiangiogenic chemotherapeutics. Symbiotic actinomycetes...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020325056 |
| _version_ | 1818958976731054080 |
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| author | Jhansi Nathan Rajaretinam Rajesh Kannan |
| author_facet | Jhansi Nathan Rajaretinam Rajesh Kannan |
| author_sort | Jhansi Nathan |
| collection | DOAJ |
| description | Blood vessel sprouting from pre-existing vessels or angiogenesis plays a significant role in tumour progression. Development of novel biomolecules from marine natural sources has a promising role in drug discovery specifically in the area of antiangiogenic chemotherapeutics. Symbiotic actinomycetes from marine origin proved to be potent and valuable sources of antiangiogenic compounds. Zebrafish represent a well-established model for small molecular screening and employed to study tumour angiogenesis over the last decade. Use of zebrafish has increased in the laboratory due to its various advantages like rapid embryo development, optically transparent embryos, large clutch size of embryos and most importantly high genetic conservation comparable to humans. Zebrafish also shares similar physiopathology of tumour angiogenesis with humans and with these advantages, zebrafish has become a popular model in the past decade to study on angiogenesis related disorders like diabetic retinopathy and cancer. This review focuses on the importance of antiangiogenic compounds from marine actinomycetes and utility of zebrafish in cancer angiogenesis research. |
| first_indexed | 2024-12-20T11:34:18Z |
| format | Article |
| id | doaj.art-11e02079badb4cd8b6190e5814101386 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-20T11:34:18Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-11e02079badb4cd8b6190e58141013862022-12-21T19:42:09ZengElsevierHeliyon2405-84402020-12-01612e05662Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer researchJhansi Nathan0Rajaretinam Rajesh Kannan1AUKBC Research Centre, Anna University, MIT Campus, Chromepet, Chennai 600044, Tamil Nadu, India; Centre for Molecular and Nanomedical Sciences, Centre for Nanoscience and Nanotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology (Deemed to be University), Chennai 600119, India; Corresponding author.Centre for Molecular and Nanomedical Sciences, Centre for Nanoscience and Nanotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology (Deemed to be University), Chennai 600119, India; Corresponding author.Blood vessel sprouting from pre-existing vessels or angiogenesis plays a significant role in tumour progression. Development of novel biomolecules from marine natural sources has a promising role in drug discovery specifically in the area of antiangiogenic chemotherapeutics. Symbiotic actinomycetes from marine origin proved to be potent and valuable sources of antiangiogenic compounds. Zebrafish represent a well-established model for small molecular screening and employed to study tumour angiogenesis over the last decade. Use of zebrafish has increased in the laboratory due to its various advantages like rapid embryo development, optically transparent embryos, large clutch size of embryos and most importantly high genetic conservation comparable to humans. Zebrafish also shares similar physiopathology of tumour angiogenesis with humans and with these advantages, zebrafish has become a popular model in the past decade to study on angiogenesis related disorders like diabetic retinopathy and cancer. This review focuses on the importance of antiangiogenic compounds from marine actinomycetes and utility of zebrafish in cancer angiogenesis research.http://www.sciencedirect.com/science/article/pii/S2405844020325056Danio rerioAngiogenesisActinomycetesBioactive moleculesTransgenic modelXenograft model |
| spellingShingle | Jhansi Nathan Rajaretinam Rajesh Kannan Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research Heliyon Danio rerio Angiogenesis Actinomycetes Bioactive molecules Transgenic model Xenograft model |
| title | Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research |
| title_full | Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research |
| title_fullStr | Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research |
| title_full_unstemmed | Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research |
| title_short | Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research |
| title_sort | antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research |
| topic | Danio rerio Angiogenesis Actinomycetes Bioactive molecules Transgenic model Xenograft model |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020325056 |
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