Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime
Primary intrahepatic rhabdomyosarcoma is an extremely rare malignant tumor. Here, we describe a case of embryonal rhabdomyosarcoma of the liver in a 7-year-old boy without any symptoms. Serologically, the patient showed abnormal levels of serum tumor markers and liver function. Imaging revealed a la...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.858219/full |
| _version_ | 1818264577300758528 |
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| author | Xu Li Xiang Li Dian-Fei Yang Miao Li Hong-Qin Xu Shuang Zheng Pu-Jun Gao |
| author_facet | Xu Li Xiang Li Dian-Fei Yang Miao Li Hong-Qin Xu Shuang Zheng Pu-Jun Gao |
| author_sort | Xu Li |
| collection | DOAJ |
| description | Primary intrahepatic rhabdomyosarcoma is an extremely rare malignant tumor. Here, we describe a case of embryonal rhabdomyosarcoma of the liver in a 7-year-old boy without any symptoms. Serologically, the patient showed abnormal levels of serum tumor markers and liver function. Imaging revealed a large mass in the left lobe of the liver and no lesions elsewhere. At first, the patient was misdiagnosed by percutaneous liver biopsy as having clear cell sarcoma. However, the final diagnosis was established to be hepatic embryonal rhabdomyosarcoma based on postoperative histopathology and typical immunohistochemical staining, which was positive for desmin and myogenin. For treatment, the patient received two cycles of preoperative chemotherapy, prophylactic radiotherapy, and 13 cycles of combined postoperative chemotherapy. Routine follow-ups after all treatment conducted by imaging examinations showed no sign of recurrence or metastasis over 13 months, and the patient survives more than 38 months since initial diagnosis. To our knowledge, this patient is the first with hepatic rhabdomyosarcoma to receive neoadjuvant chemotherapy (preoperative chemotherapy) combined with relative comprehensive treatment and achieve a favorable result. |
| first_indexed | 2024-12-12T19:37:07Z |
| format | Article |
| id | doaj.art-11e2626d45c44e7d8897cd7adceba2db |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T19:37:07Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-11e2626d45c44e7d8897cd7adceba2db2022-12-22T00:14:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.858219858219Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum LifetimeXu Li0Xiang Li1Dian-Fei Yang2Miao Li3Hong-Qin Xu4Shuang Zheng5Pu-Jun Gao6Department of Hepatology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hepatology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatric Oncology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pathology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hepatology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Radiology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hepatology, The First Hospital of Jilin University, Changchun, ChinaPrimary intrahepatic rhabdomyosarcoma is an extremely rare malignant tumor. Here, we describe a case of embryonal rhabdomyosarcoma of the liver in a 7-year-old boy without any symptoms. Serologically, the patient showed abnormal levels of serum tumor markers and liver function. Imaging revealed a large mass in the left lobe of the liver and no lesions elsewhere. At first, the patient was misdiagnosed by percutaneous liver biopsy as having clear cell sarcoma. However, the final diagnosis was established to be hepatic embryonal rhabdomyosarcoma based on postoperative histopathology and typical immunohistochemical staining, which was positive for desmin and myogenin. For treatment, the patient received two cycles of preoperative chemotherapy, prophylactic radiotherapy, and 13 cycles of combined postoperative chemotherapy. Routine follow-ups after all treatment conducted by imaging examinations showed no sign of recurrence or metastasis over 13 months, and the patient survives more than 38 months since initial diagnosis. To our knowledge, this patient is the first with hepatic rhabdomyosarcoma to receive neoadjuvant chemotherapy (preoperative chemotherapy) combined with relative comprehensive treatment and achieve a favorable result.https://www.frontiersin.org/articles/10.3389/fmed.2022.858219/fullrhabdomyosarcomaembryonalhepaticliverdiagnosis |
| spellingShingle | Xu Li Xiang Li Dian-Fei Yang Miao Li Hong-Qin Xu Shuang Zheng Pu-Jun Gao Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime Frontiers in Medicine rhabdomyosarcoma embryonal hepatic liver diagnosis |
| title | Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime |
| title_full | Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime |
| title_fullStr | Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime |
| title_full_unstemmed | Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime |
| title_short | Case Report: Pediatric Hepatic Rhabdomyosarcoma With Maximum Lifetime |
| title_sort | case report pediatric hepatic rhabdomyosarcoma with maximum lifetime |
| topic | rhabdomyosarcoma embryonal hepatic liver diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.858219/full |
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