Case report: Prazosin augmentation for treating comorbid treatment-resistant depression and chronic post-traumatic stress disorder

Case report: Prazosin augmentation for treating comorbid treatment-resistant depression and chronic post-traumatic stress disorder

Psychological trauma in childhood can lead to post-traumatic disorder (PTSD) with protracted comorbid depression, which responds poorly to conventional antidepressants. Previous studies have shown that prazosin, an α1-adrenergic receptor antagonist, can help eliminate nightmares and improve sleep qu...

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Bibliographic Details
Main Authors: Ping Guo, Yu Fang, Ming Feng, Xudong Zhao, Shikai Wang, Mincai Qian, Juanjuan Huang, Huanxin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Psychiatry
Subjects:
Prazosin
post-traumatic stress disorder
treatment-resistant depression
cognitive function
sleep disturbance
comorbidity
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.803220/full

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